Distributor inventory

Treatment of anxiety disorders (short-term); adjunct treatment of epilepsy/seizure disorders (e.g., Lennox-Gastaut syndrome) as prescribed

Clobazam is a benzodiazepine that enhances the effect of the inhibitory neurotransmitter GABA in the brain by acting on GABA-A receptors. This reduces excessive nerve activity, producing anxiolytic and anticonvulsant effects.

Take by mouth exactly as prescribed. Can be taken with or without food; take at the same time each day. Swallow tablet with water; do not stop suddenly—dose should be tapered under medical supervision.

Drowsiness, dizziness, fatigue, sleepiness/sedation, impaired coordination, confusion, headache, constipation, nausea

May cause sedation, dizziness and impaired driving/operating machinery. Risk of dependence, tolerance and withdrawal—do not stop abruptly. Use caution in elderly, depression, history of substance misuse, respiratory disease/sleep apnea, liver impairment. Avoid other CNS depressants (including opioids) due to risk of severe sedation/respiratory depression. May increase suicidal thoughts/behavior in some patients; monitor. Use only on prescription.

Alcohol and other CNS depressants (opioids, sedative antihistamines, antipsychotics) increase sedation/respiratory depression; CYP2C19 inhibitors (e.g., omeprazole, fluconazole, fluvoxamine) may increase active metabolite levels; enzyme inducers (e.g., carbamazepine, phenytoin, phenobarbital, rifampicin) may reduce effect; valproate may increase sedation; cannabis may increase drowsiness

Store below 25°C in a dry place, protected from moisture and light. Keep out of reach of children.

Frisium 10 Tablet, Clobazam 10 Tablet, Clonotril 10 (if available as clobazam brand varies), Clobaz 10 Tablet, Clobazam 10 mg tablets (generic)