Glimefort-M1 Tab

Tablet

Treatment of type 2 diabetes mellitus in adults when diet and exercise alone (or single drug therapy) are insufficient; helps control high blood sugar and reduce diabetes-related complications.

Glimepiride is a sulfonylurea that increases insulin release from the pancreas and improves peripheral glucose utilization. Metformin reduces glucose production in the liver and improves insulin sensitivity, lowering intestinal glucose absorption and improving glycaemic control.

Take by mouth exactly as prescribed. Usually taken once daily with or just after a meal (preferably breakfast) to reduce stomach upset and risk of hypoglycaemia. Swallow tablets whole (do not crush/chew if modified-release). Monitor blood glucose regularly.

Hypoglycaemia, nausea, vomiting, diarrhoea, abdominal pain, loss of appetite, metallic taste, headache, dizziness, weight gain, skin rash

Use only in type 2 diabetes (not for type 1 diabetes or diabetic ketoacidosis). Risk of hypoglycaemia (higher with missed meals, excessive exercise, alcohol, or other antidiabetics); keep fast-acting glucose available. Metformin can rarely cause lactic acidosis—risk increases with severe kidney impairment, dehydration, severe infection, shock, or excess alcohol; dose adjustment/avoid in renal impairment. Use caution in liver disease, heart failure, elderly, and during fasting. Stop temporarily before/after iodinated contrast studies and major surgery as advised by doctor. Inform doctor if symptoms of lactic acidosis occur (rapid breathing, severe weakness, abdominal pain, unusual sleepiness).

Insulin and other antidiabetics (increased hypoglycaemia), alcohol (increased hypoglycaemia and lactic acidosis risk), corticosteroids and diuretics (may increase glucose), beta-blockers (mask hypoglycaemia symptoms), ACE inhibitors (may enhance glucose-lowering), fluoroquinolones (dysglycaemia), azole antifungals/macrolides (may increase sulfonylurea effect), rifampicin (may reduce effect), iodinated contrast media (lactic acidosis risk with metformin), cimetidine (increases metformin levels)

Store below 25°C in a dry place, protected from moisture and light. Keep in original blister pack and out of reach of children.

Glimestar M1 Tablet, Amaryl M 1 Tablet, Glimy M 1 Tablet, Glycomet-GP 1 Tablet, Glimepiride+Metformin 1 mg/500 mg tablets (various brands)