Glimison M1 Tab

Tablet

Management of type 2 diabetes mellitus in adults when diet and exercise alone or single-drug therapy is inadequate; helps control high blood sugar and reduces risk of diabetes-related complications.

Glimepiride (a sulfonylurea) increases insulin release from the pancreas and improves the body’s response to insulin. Metformin (a biguanide) decreases glucose production in the liver and reduces intestinal glucose absorption while improving insulin sensitivity, leading to better blood glucose control.

Oral tablet. Take exactly as prescribed, usually once daily with breakfast or the first main meal (to reduce stomach upset and risk of low sugar). Swallow with water; do not crush/chew unless advised. Monitor blood glucose regularly; maintain diet and exercise as advised.

Hypoglycaemia (low blood sugar),nausea,diarrhoea,abdominal pain,loss of appetite,metallic taste,headache,dizziness,weight gain (glimepiride),rash

Risk of hypoglycaemia especially with missed meals, excess exercise, alcohol intake, or with other antidiabetic medicines—carry glucose/sugar. Metformin may rarely cause lactic acidosis (medical emergency); risk increases with kidney impairment, dehydration, severe infection, heart/respiratory failure, or heavy alcohol use—avoid if significant renal dysfunction. Periodically monitor kidney function, liver function, and vitamin B12 with long-term use. Temporarily stop metformin before/after iodinated contrast studies and major surgery as advised by doctor. Use caution in elderly and in patients with irregular eating patterns.

Alcohol (increases risk of hypoglycaemia and lactic acidosis),insulin/other antidiabetics (additive hypoglycaemia),beta-blockers (may mask hypoglycaemia symptoms),corticosteroids and thiazide/loop diuretics (may raise blood sugar),ACE inhibitors (may enhance glucose-lowering),fluoroquinolones (may cause hypo/hyperglycaemia),iodinated contrast media (lactic acidosis risk with metformin),cimetidine (may increase metformin levels)

Store below 25°C in a cool, dry place. Protect from moisture and direct light. Keep in original blister pack and out of reach of children.

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