Glimital M2 Tab

Tablet

Type 2 diabetes mellitus (adult) to improve blood glucose control along with diet and exercise when dual therapy is needed.

Glimepiride is a sulfonylurea that increases insulin release from pancreatic beta cells and improves insulin sensitivity. Metformin reduces glucose production by the liver and improves peripheral glucose uptake, lowering fasting and post-meal blood sugar.

Oral tablet. Take exactly as prescribed, usually once daily with or immediately after food (preferably with breakfast) to reduce stomach upset and hypoglycaemia risk. Swallow whole if modified/extended release; do not crush or chew. Monitor blood glucose regularly.

Hypoglycaemia, nausea, vomiting, diarrhoea, abdominal pain, loss of appetite, metallic taste, headache, dizziness, weight gain (glimepiride), rash

Risk of hypoglycaemia (higher with missed meals, alcohol, strenuous exercise, elderly, kidney/liver impairment). Metformin may rarely cause lactic acidosis—risk increases with significant kidney disease, dehydration, severe infection, heart/respiratory failure, shock, and excessive alcohol intake. Check renal function before starting and periodically; stop temporarily before/after iodinated contrast procedures and major surgery as advised. Use caution in hepatic impairment. Not for type 1 diabetes or diabetic ketoacidosis. Seek care for symptoms of low sugar or lactic acidosis (extreme weakness, fast breathing, abdominal discomfort).

Alcohol, insulin/other antidiabetics (additive hypoglycaemia), beta-blockers (mask hypoglycaemia symptoms), corticosteroids and thiazide diuretics (raise glucose), ACE inhibitors (may increase hypoglycaemia risk), fluoroquinolones (dysglycaemia), rifampicin (reduces sulfonylurea effect), azole antifungals and macrolides (may increase sulfonylurea levels), iodinated contrast media (lactic acidosis risk with metformin), cimetidine (increases metformin levels)

Store below 25°C in a cool, dry place. Protect from moisture and direct light. Keep in original blister pack and out of reach of children.

Amaryl M 2 Tablet, Glim M2 Tablet, Glycomet-GP 2 Tablet, Glimepiride+Metformin 2 mg/500 mg Tablet (generic), Zoryl-M 2 Tablet