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Delivered across India. ₹49 delivery, free above ₹999.
Pack: Tablet · 10 Tablet
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Contains: Glipizide 5mg + Metformin 500mg
Glucomust M 5/500 Tablet contains Glipizide 5mg + Metformin 500mg. Prescription required.
Glucomust M 5/500 Tablet is a prescription medicine containing Glipizide 5mg + Metformin 500mg. It is used for add-on therapy when fasting, post‑prandial glucose remain elevated despite diet and exercise. It belongs to the group of medicines called Sulfonylurea and Biguanide.
Glucomust M 5/500 Tablet is usually taken 1 tablet once daily with breakfast or the main meal initially; if prescribed twice daily, take with breakfast and dinner to reduce gastrointestinal upset and hypoglycaemia. The dose and how long you take it depend on what you are being treated for and how you respond. Do not take more, or for longer, than your doctor has advised.
The side effects seen most often with Glucomust M 5/500 Tablet are lactic acidosis, severe/prolonged hypoglycaemia, cholestatic jaundice/hepatitis and blood dyscrasias (leukopenia, thrombocytopenia). Most are mild and settle as the body gets used to the medicine. Tell your doctor if one persists or worries you.
Before you start, tell your doctor about any liver, kidney or heart problem, whether you are pregnant, planning a pregnancy or breastfeeding, and every other medicine you take, including supplements and ayurvedic preparations. Some of them can change how Glucomust M 5/500 Tablet works.
Most side effects of Glucomust M 5/500 are mild and settle as the body gets used to the medicine. The ones reported most often are:
Stop the medicine and get help at once for a rash, swelling of the face or lips, wheezing or difficulty breathing. Tell your doctor about any side effect that persists or worries you.
Glucomust M 5/500 Tablet is usually taken 1 tablet once daily with breakfast or the main meal initially; if prescribed twice daily, take with breakfast and dinner to reduce gastrointestinal upset and hypoglycaemia. Swallow whole with water; do not skip meals after taking the 5mg glipizide/500mg metformin combination.
Glipizide closes pancreatic beta‑cell ATP‑sensitive K+ (KATP; SUR1) channels, depolarising the cell and increasing Ca2+ influx to trigger insulin release. Metformin activates AMP‑activated protein kinase (AMPK), suppressing hepatic gluconeogenesis and improving peripheral insulin sensitivity while decreasing intestinal glucose absorption.
Hypoglycaemia risk is higher with missed meals, heavy exercise, alcohol use, elderly patients, or renal impairment—carry fast‑acting glucose. Metformin component: monitor eGFR before start and periodically; dose review advised when eGFR 30–45 and avoid initiation; stop during dehydration, severe infection, or hypoxic states. Lactic acidosis warning—seek urgent care for rapid breathing, persistent vomiting, severe weakness, abdominal pain. Hepatic impairment increases lactic acidosis/hypoglycaemia risk. Pregnancy: insulin preferred for diabetes management; use only if clinician considers benefit > risk. Breastfeeding: metformin appears in milk in small amounts; glipizide may cause infant hypoglycaemia—medical advice required. Vitamin B12 deficiency can occur with long‑term metformin—periodic B12 assessment in anaemia/neuropathy.
Take it as soon as you remember. If your next dose is almost due, skip the one you missed — never take two doses together to catch up.
An overdose of this medicine can cause severe and prolonged low blood sugar, which may lead to fits or unconsciousness. It can cause a dangerous build-up of acid in the blood, with vomiting, severe weakness and laboured breathing. Do not wait for symptoms to appear — go to the nearest emergency department and take the pack or strip with you.
Alcohol increases risk of metformin‑associated lactic acidosis and potentiates hypoglycaemia; iodinated contrast media can precipitate acute kidney injury leading to metformin accumulation/lactic acidosis; insulin or other antidiabetics (e.g., linagliptin, empagliflozin) additively increase hypoglycaemia risk; beta‑blockers (e.g., propranolol) mask adrenergic warning signs of hypoglycaemia; fluoroquinolones (e.g., levofloxacin) may cause dysglycaemia; corticosteroids/diuretics (prednisolone, hydrochlorothiazide) raise glucose and reduce efficacy; cimetidine reduces metformin renal clearance via OCT2/MATE inhibition increasing exposure; ACE inhibitors (e.g., enalapril) may enhance glucose‑lowering causing hypoglycaemia in some patients; NSAIDs may increase sulfonylurea effect and hypoglycaemia.
Store at 20–25°C; protect from moisture and direct light; keep in original blister pack.
Glycomet-GP 2 Tablet (Glipizide 5mg + Metformin 500mg); Glucored-GP 2 Tablet (Glipizide 5mg + Metformin 500mg); Glipimet 5/500 Tablet (Glipizide 5mg + Metformin 500mg)
Compiled from the manufacturer's prescribing information and the sources below, and reviewed by a registered pharmacist. It does not replace your own doctor's advice.
Medical disclaimer: product information is for awareness only and does not replace medical advice. For Rx medicines, a valid prescription is required. Consult your doctor or pharmacist for personalised guidance.
Mankind (Pharma)
Tablet · 40mg + 10mg + 6.25mg · 10 S
₹113.22
Prescription needed
