Itrasol 200

Itraconazole (200mg)

Treatment of fungal infections such as aspergillosis, histoplasmosis, blastomycosis; dermatophytosis (tinea/ringworm), pityriasis versicolor; candidiasis (oral/esophageal/vaginal); onychomycosis (nail fungal infection) as prescribed.

Itraconazole is a triazole antifungal that inhibits fungal CYP450 enzyme 14-alpha-demethylase, reducing ergosterol synthesis. This disrupts the fungal cell membrane and stops fungal growth, leading to clearance of infection.

Capsule: take exactly as prescribed. Usually taken with food (better absorption); swallow whole and do not crush/chew. Take at the same time each day; duration depends on infection type and site. Avoid taking with acid-suppressing medicines unless advised.

Nausea, abdominal pain, diarrhea, headache, dizziness, rash, elevated liver enzymes, peripheral edema

Prescription-only antifungal. Can cause liver injury—seek care for jaundice, dark urine, severe fatigue; monitoring may be needed, especially with prolonged therapy. May worsen or precipitate heart failure—avoid/use with extreme caution in patients with ventricular dysfunction/CHF. Numerous serious drug interactions due to strong CYP3A4 inhibition; do not self-medicate. Use caution in kidney/liver disease and in the elderly.

Strong interactions via CYP3A4: statins (simvastatin/lovastatin), antiarrhythmics (quinidine, dofetilide, dronedarone), benzodiazepines (midazolam, triazolam), ergot alkaloids, certain antihistamines (terfenadine/astemizole), some calcium channel blockers, warfarin, digoxin, cyclosporine/tacrolimus, oral hypoglycemics. Reduced absorption with PPIs/H2 blockers/antacids. Rifampicin, phenytoin, carbamazepine, efavirenz reduce itraconazole levels.

Store below 25°C in a dry place, protected from moisture and light. Keep in original pack and out of reach of children.

Sporanox 200 Capsule, Canditral 200 Capsule, Itrasys 200 Capsule, Itaspor 200 Capsule, Itracon 200 Capsule