Nexpro Rd 20 Cap 10S

Capsule

Gastroesophageal reflux disease (GERD), heartburn/acid reflux, gastritis and peptic ulcer disease associated acidity, nausea/vomiting associated with reflux or delayed gastric emptying

Esomeprazole is a proton pump inhibitor that reduces stomach acid by blocking the H+/K+ ATPase pump in gastric parietal cells. Domperidone is a peripheral dopamine (D2) receptor antagonist that increases gastric motility and helps relieve nausea and vomiting.

Capsule (with SR domperidone): take as prescribed, usually once daily 30 minutes before food (preferably before breakfast). Swallow whole; do not crush or chew. If a dose is missed, take it when remembered unless it is close to the next dose.

Headache, diarrhea, constipation, abdominal pain, nausea, dry mouth, dizziness, flatulence

Use with caution in liver disease. Domperidone may increase risk of QT prolongation/serious heart rhythm problems; avoid in patients with known QT prolongation, significant cardiac disease, or with electrolyte disturbances (low potassium/magnesium). Not recommended in moderate to severe hepatic impairment. Long-term PPI use may be associated with low magnesium, vitamin B12 deficiency, fractures, and increased infection risk (e.g., C. difficile); use lowest effective dose. Seek medical advice if alarm symptoms occur (blood in vomit/black stools, unexplained weight loss, persistent vomiting, difficulty swallowing).

QT-prolonging drugs (e.g., amiodarone, sotalol, certain antipsychotics/antidepressants), strong CYP3A4 inhibitors (e.g., ketoconazole, itraconazole, erythromycin, clarithromycin, ritonavir) increase domperidone levels and arrhythmia risk; warfarin (monitor), clopidogrel (reduced activation possible with some PPIs), digoxin (levels may increase), methotrexate (high-dose—PPI may raise levels), drugs needing acidic pH for absorption (e.g., ketoconazole, atazanavir)

Store below 25°C in a dry place, protected from light and moisture. Keep in original blister pack and out of reach of children.

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