Pioglar-G-Tab 10S

Pioglar-G-Tab 10S contains Pioglitazone (15mg) + Glimepiride (2mg). Prescription required.

Type 2 diabetes mellitus (adult) to improve blood glucose control when diet and exercise alone are not sufficient

Glimepiride (a sulfonylurea) increases insulin release from the pancreas and improves glucose utilization. Pioglitazone (a thiazolidinedione/PPAR-γ agonist) improves insulin sensitivity in muscle and fat and reduces hepatic glucose production.

Tablet for oral use. Take exactly as prescribed, usually once daily with the first main meal to reduce risk of low blood sugar. Swallow whole with water; do not skip meals. Regularly monitor blood glucose as advised.

Hypoglycaemia, dizziness, headache, nausea, weight gain, oedema (swelling), upper respiratory tract infection, diarrhoea

Risk of hypoglycaemia (especially if meals are skipped or with other antidiabetics); may cause weight gain and fluid retention—can worsen or precipitate heart failure (avoid in NYHA class III/IV; use caution in cardiac disease); monitor for oedema and shortness of breath. Pioglitazone may increase risk of fractures and can cause/ worsen macular oedema; report vision changes. Use caution in liver disease; check liver enzymes if symptoms of hepatitis occur. Not for type 1 diabetes or diabetic ketoacidosis.

Other antidiabetic medicines/insulin (increased hypoglycaemia risk), beta-blockers (may mask hypoglycaemia symptoms), rifampicin (may reduce pioglitazone effect), azole antifungals and other CYP2C9 inhibitors like fluconazole (may increase glimepiride effect), gemfibrozil (may increase pioglitazone levels), corticosteroids/thyroid hormones/diuretics (may raise blood glucose)

Store below 25°C in a dry place, protected from moisture and light. Keep in original blister pack and out of reach of children.

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