Pregaba 50 Capsule

Drug | Capsule

Neuropathic pain (e.g., diabetic neuropathy, post-herpetic neuralgia), neuropathic pain associated with spinal cord injury, fibromyalgia, adjunct treatment of partial-onset seizures, generalized anxiety disorder (where prescribed).

Pregabalin binds to the alpha-2-delta subunit of voltage-gated calcium channels in the central nervous system. This reduces release of excitatory neurotransmitters and decreases abnormal nerve signal transmission, thereby relieving neuropathic pain and reducing seizure tendency.

Oral capsule. Take exactly as prescribed, with or without food, preferably at the same time each day. Swallow whole with water; do not crush or chew. Dose is usually titrated gradually; do not stop suddenly—taper as advised to avoid withdrawal symptoms.

Dizziness, sleepiness (somnolence), blurred vision, dry mouth, weight gain, peripheral edema (swelling), fatigue, difficulty concentrating, increased appetite, constipation

May cause dizziness and drowsiness—avoid driving/operating machinery until effects are known. Do not stop abruptly; risk of withdrawal symptoms and seizure worsening. Use with caution in kidney disease (dose adjustment required). Risk of edema and weight gain; caution in heart failure. Monitor for mood changes/suicidal thoughts. Hypersensitivity/angioedema and serious skin reactions can occur—seek urgent care if swelling of face/tongue or breathing difficulty occurs.

Alcohol (increases sedation), opioids (e.g., morphine, oxycodone) and other CNS depressants (increased drowsiness/respiratory depression risk), benzodiazepines, antihistamines/sedatives, ACE inhibitors (higher risk of angioedema), thiazolidinediones like pioglitazone (increased edema/weight gain)

Store below 25°C in a cool, dry place. Protect from light and moisture. Keep in original pack and out of reach of children.

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