UFORMIN-500 SR TAB

Distributor inventory | Tablet

Type 2 diabetes mellitus (to control blood glucose)

Metformin reduces glucose production in the liver and decreases intestinal glucose absorption. It also improves insulin sensitivity in peripheral tissues, helping lower blood sugar without usually causing hypoglycaemia when used alone.

Take by mouth as directed by doctor, usually once daily with the evening meal or with food. Swallow the sustained-release tablet whole; do not crush, break or chew. Regularly monitor blood glucose; continue diet and exercise advice.

Nausea, vomiting, diarrhoea, abdominal pain, loss of appetite, metallic taste, headache

Risk of lactic acidosis (rare but serious), especially with kidney impairment, dehydration, severe infection, shock, liver disease, or excessive alcohol use. Dose adjustment/avoid in reduced renal function; monitor eGFR periodically. Temporarily stop before/after iodinated contrast procedures and during major surgery as advised. Long-term use may cause vitamin B12 deficiency; consider periodic monitoring. Use caution in elderly and in conditions causing poor oxygenation.

Alcohol, iodinated contrast media, carbonic anhydrase inhibitors (e.g., topiramate, acetazolamide), cimetidine, diuretics, corticosteroids, beta-agonists, thyroid hormones, antipsychotics (e.g., olanzapine), ACE inhibitors/ARBs and other antidiabetics/insulin (may increase hypoglycaemia risk when combined)