Distributor inventory

Type 2 diabetes mellitus (as an adjunct to diet and exercise) when glycaemic control is inadequate with metformin alone or when already treated with vildagliptin and metformin.

Vildagliptin is a DPP-4 inhibitor that increases incretin hormones (GLP-1, GIP), leading to increased insulin release and reduced glucagon in a glucose-dependent manner. Metformin reduces hepatic glucose production and improves insulin sensitivity, lowering blood glucose levels.

Oral tablet. Take with food to reduce stomach upset; usually taken once or twice daily as prescribed. Swallow whole with water; do not crush/chew. Dose and schedule should be individualized based on blood sugar, kidney function and tolerance.

Nausea, vomiting, diarrhoea, abdominal pain, loss of appetite, headache, dizziness, tremor, hypoglycaemia (especially with other antidiabetics), upper respiratory tract infection, elevated liver enzymes

Prescription medicine. Risk of lactic acidosis with metformin (higher risk in severe kidney disease, dehydration, sepsis, hypoxia, excessive alcohol use); stop and seek urgent care if severe weakness, rapid breathing, abdominal pain or drowsiness occur. Check kidney function before and during therapy; not recommended in severe renal impairment. Monitor liver function with vildagliptin; discontinue if jaundice or persistent LFT elevation. Use caution in pancreatitis history; stop if severe persistent abdominal pain. Hold metformin on the day of iodinated contrast procedures and during major surgery as advised by doctor.

Alcohol (increases lactic acidosis risk), iodinated contrast media, carbonic anhydrase inhibitors (e.g., topiramate/acetazolamide), cimetidine, diuretics, ACE inhibitors/ARBs (may affect glucose), corticosteroids, thiazide diuretics, sympathomimetics, other antidiabetics/insulin (increased hypoglycaemia risk)

Store below 25°C in a cool, dry place. Protect from moisture and direct light. Keep in original blister pack and out of reach of children.

Galvus Met 50/500 Tablet, Jalra-M 50/500 Tablet, Zomelis Met 50/500 Tablet, Vildamet 50/500 Tablet, Vysov-M 50/500 Tablet