Distributor inventory | Tablet

Gastroesophageal reflux disease (GERD), heartburn and acid regurgitation, erosive esophagitis, peptic/duodenal ulcer, prevention of NSAID-induced ulcers, Helicobacter pylori eradication (with antibiotics), Zollinger–Ellison syndrome

Esomeprazole is a proton pump inhibitor (PPI). It irreversibly blocks the gastric H+/K+ ATPase pump in stomach parietal cells, reducing acid secretion and allowing healing of acid-related damage.

Oral tablet. Usually taken once daily, preferably 30–60 minutes before food (often before breakfast). Swallow whole; do not crush or chew. Duration and dose as prescribed; for H. pylori it is used with antibiotics.

Headache, diarrhea, nausea, abdominal pain, flatulence, constipation, dizziness

Use with caution in severe liver disease. Long-term use may increase risk of vitamin B12 deficiency, low magnesium, bone fractures, kidney inflammation (interstitial nephritis) and certain infections (e.g., C. difficile). Seek medical advice if alarm symptoms occur (unintentional weight loss, persistent vomiting, difficulty swallowing, blood in vomit/stool). May mask symptoms of gastric cancer; evaluation may be needed if symptoms persist.

Warfarin (INR changes), clopidogrel (reduced activation/antiplatelet effect), diazepam (increased levels), phenytoin (increased levels), digoxin (increased levels), methotrexate (increased levels at high dose), tacrolimus (increased levels), ketoconazole/itraconazole/posaconazole and iron salts (reduced absorption), atazanavir/nelfinavir (reduced levels; avoid)

Store below 25°C, in a dry place, protected from light and moisture. Keep in original blister pack and out of reach of children.

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