ZOMSET D 40MG CAP

Distributor inventory | Capsule

Gastroesophageal reflux disease (GERD), acidity/heartburn, gastritis, indigestion (dyspepsia) associated with nausea/vomiting due to reflux

Pantoprazole is a proton pump inhibitor that reduces stomach acid by blocking the H+/K+ ATPase pump in gastric parietal cells. Domperidone is a dopamine (D2) receptor antagonist that enhances gastric motility and has anti-nausea action, helping reduce reflux symptoms.

Oral capsule. Usually taken once daily, 30 minutes before food (preferably before breakfast). Swallow whole; do not crush or chew. Use as directed by a doctor.

Headache, diarrhoea, abdominal pain, nausea, flatulence, dry mouth, dizziness

Use with caution in liver disease. Domperidone may increase risk of QT prolongation/serious heart rhythm problems—avoid in patients with known QT prolongation, significant electrolyte disturbances, or heart failure; do not exceed prescribed dose. Long-term PPI use may be associated with low magnesium, vitamin B12 deficiency, fractures, and increased risk of gastrointestinal infections; use the lowest effective dose. Seek medical advice if alarm symptoms occur (blood in stool/vomit, persistent vomiting, unexplained weight loss, difficulty swallowing).

QT-prolonging drugs (e.g., amiodarone, sotalol, certain antipsychotics), strong CYP3A4 inhibitors (e.g., ketoconazole, itraconazole, clarithromycin, erythromycin, ritonavir) increase domperidone levels/arrhythmia risk; anticoagulants (e.g., warfarin) may need monitoring; drugs needing acidic pH for absorption (e.g., ketoconazole, atazanavir, iron salts) may have reduced absorption with pantoprazole; high-dose methotrexate (PPIs may increase levels)