Zyven-OD 50MG Tab

Tablet

Treatment of major depressive disorder (depression); may also be used for anxiety symptoms associated with depression as prescribed.

Desvenlafaxine is a serotonin-norepinephrine reuptake inhibitor (SNRI). It increases levels of serotonin and norepinephrine in the brain, helping improve mood, energy and interest in daily activities.

Oral tablet (OD/once daily). Take exactly as prescribed, preferably at the same time each day, with or without food. Swallow whole; do not crush, chew or split extended-release tablets. Do not stop suddenly without medical advice.

nausea, dizziness, headache, dry mouth, constipation, sweating, insomnia, sleepiness, decreased appetite, increased blood pressure, sexual dysfunction

Prescription medicine. Do not use with MAO inhibitors (or within 14 days of stopping an MAOI); wait at least 7 days after stopping desvenlafaxine before starting an MAOI. Monitor for suicidal thoughts/behavior especially in young adults and during dose changes. May increase blood pressure and heart rate—regular BP monitoring advised. Use caution in seizure disorder, bipolar disorder/mania, bleeding disorders, glaucoma (angle-closure risk), hyponatremia risk (elderly/diuretics), and liver/kidney impairment (dose adjustment may be needed). Risk of serotonin syndrome, especially with other serotonergic drugs. Do not stop abruptly—withdrawal symptoms may occur.

MAO inhibitors (contraindicated), other serotonergic drugs (SSRIs/SNRIs, triptans, tramadol, linezolid, lithium, St John’s wort) increasing serotonin syndrome risk, NSAIDs/aspirin/anticoagulants (increased bleeding risk), alcohol/CNS depressants (additive dizziness/sedation), drugs that raise blood pressure (additive effect), strong CYP3A4 inhibitors may increase levels (clinically modest)

Store below 25°C in a dry place, protected from light and moisture. Keep out of reach of children.

D-Veniz XR 50 Tablet, Desvenlafaxine ER 50 mg Tablet (generic), Pristiq 50 mg (Desvenlafaxine ER), Deswell 50 XR Tablet, Desnexa XR 50 Tablet