
Acuclav 375
Macleods Pharmaceuticals Pvt Ltd - 10 S
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Cefixime (100mg) + Cloxacillin (500mg)
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Cefolac XL 100 is used for bacterial infections.
Medically reviewed by Dr. Balaji Krishnan, MBBS · Updated September 2026
Cefolac XL 100 contains Cefixime (100mg) + Cloxacillin (500mg). It belongs to the Cephalosporin and Penicillin class of medicines.
Bacterial infections
Cefolac 100mg/500mg Tablet XL is a combination of two antibiotics: Cefixime and Cloxacillin. These antibiotics work by preventing the formation of the bacterial protective covering which is essential for the survival of bacteria in the human body. Together, they treat your infection effectively.
Take exactly as prescribed by your doctor.
Most side effects of Cefolac XL are mild and settle as the body adjusts. Reported side effects include:
Stop the medicine and seek help immediately for a rash, swelling of the face or lips, wheezing or difficulty breathing. Tell your doctor about any side effect that persists or worries you.
| Pregnancy | Pregnancy CONSULT YOUR DOCTOR |
|---|---|
| Breastfeeding | Breast feeding CAUTION |
| Alcohol | Alcohol CAUTION |
| Driving | Driving UNSAFE |
| Kidney | Kidney CONSULT YOUR DOCTOR |
| Liver | Liver CONSULT YOUR DOCTOR |
| Habit forming | No |
Finish the whole course even after you feel better — stopping early breeds resistant bacteria. Tell your doctor if you have ever had a severe reaction to penicillin; a small proportion of people react to both groups. Report severe or watery loose motions during or after the course rather than treating them yourself. Several medicines in this group are on Schedule H1 precisely because overuse drives antibiotic resistance. Take it only when a doctor has prescribed it for you. Finish the whole course even after you feel better. Stopping early lets the strongest bacteria survive, and they are the ones that come back resistant. Stop and seek emergency care for swelling of the face or throat, difficulty breathing, or a widespread rash — a penicillin allergy can be serious. Tell every doctor and pharmacist if you have ever reacted to penicillin. Tell your doctor if loose motions become severe or watery, or continue after the course — this needs attention rather than an anti-diarrhoeal. Antibiotics do not work against colds, flu or most sore throats, which are caused by viruses.
Not for anyone with a known allergy to this medicine or to any ingredient in the pack. Not for anyone with a known allergy to cephalosporin antibiotics. Not for anyone with a known penicillin allergy.
Antacids, iron and zinc reduce absorption — separate them by a couple of hours. Tell your doctor if you take a blood thinner. May reduce the reliability of the oral contraceptive pill if you have vomiting or loose motions — use additional precautions during the course. Tell your doctor if you take methotrexate or a blood thinner.
Store below 30°C in the original pack, away from direct sunlight and moisture. Keep out of the reach of children.
You have been prescribed this combination medicine to treat bacterial infections. Finish the prescribed course, even if you start to feel better. Stopping it early may make the infection come back and harder to treat. Stop taking Cefolac 100mg/500mg Tablet XL and inform your doctor immediately if you develop an itchy rash, swelling of the face, throat or tongue or breathing difficulties while taking it.

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The information on Cefolac XL 100 is compiled from the manufacturer's prescribing information and the sources below, and is reviewed by a registered medical practitioner. It does not replace advice from your own doctor.