
Cetaphil 100GM Bar
Cetaphil - 100 gm - 100 G
Urea 4% w/w topical lotion (other base emollients/humectants may be present)
Cetaphil Pro Urea 4% Smoothing Hydrating Lotion is used for dry to very dry rough skin, keratosis pilaris-like roughness, scaling, barrier impairment, smoothing and hydration support.
Medically reviewed by Dr. Balaji Krishnan, MBBS · Updated September 2026
Cetaphil Pro Urea 4% Smoothing Hydrating Lotion contains Urea 4% w/w topical lotion (other base emollients/humectants may be present). It belongs to the Urea (topical keratolytic and humectant) class of medicines.
Urea is a keratolytic and humectant: it attracts and binds water in the stratum corneum and helps soften and loosen hardened, scaly skin. This improves smoothness while enhancing hydration and barrier function.
For external use only. Apply a thin layer to affected areas once or twice daily, preferably after bathing. Avoid application on broken or severely irritated skin unless advised.
Take it exactly as your doctor prescribed. Do not change the dose or stop early on your own.
Take the missed dose of Cetaphil Pro Urea 4% Smoothing Hydrating as soon as you remember. If it is almost time for the next dose, skip the missed one and carry on with the usual schedule. Do not take two doses together to make up for a missed dose.
An overdose of this medicine is not a realistic risk from a moisturiser used on the skin. Do not wait for symptoms to appear — go to the nearest emergency department and take the pack or strip with you.
Most side effects of Cetaphil Pro Urea 4% Smoothing Hydrating are mild and settle as the body adjusts. Reported side effects include:
Stop the medicine and seek help immediately for a rash, swelling of the face or lips, wheezing or difficulty breathing. Tell your doctor about any side effect that persists or worries you.
| Pregnancy | Generally safe |
|---|---|
| Breastfeeding | Generally considered safe while breastfeeding. |
| Alcohol | No known interaction |
| Driving | Not expected to affect your ability to drive. |
| Kidney | No dose change is usually needed in kidney disease. |
| Liver | No dose change is usually needed in liver disease. |
| Habit forming | No |
Avoid eyes, mouth and mucous membranes. If significant irritation occurs, stop use and consult a doctor. Use caution in children and on sensitive/fissured skin as urea may sting.
Not for anyone with a known allergy to this medicine or to any ingredient in the pack.
No significant systemic interactions expected; combining with other exfoliants (AHA/BHA/retinoids) may increase irritation
Store below 30°C, protect from heat and sunlight, keep tightly closed.
Use lukewarm water, a soap substitute and short baths. Smooth it on in the direction the hair grows rather than rubbing it in hard. Keep using it when the skin looks normal — that is what prevents the next flare.

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The information on Cetaphil Pro Urea 4% Smoothing Hydrating Lotion is compiled from the manufacturer's prescribing information and the sources below, and is reviewed by a registered medical practitioner. It does not replace advice from your own doctor.