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Prescription requiredZydus Healthcare PharmaTopical corticosteroid and Anti-acne agent

Clop-S 3.5 Nano Lotion

Clobetasol (0.05%w/w) + Salicylic Acid (3.5%w/w)

Clop-S 3.5 Nano Lotion is used for this medicine is used in the treatment of eczema, dermatitis, psoriasis, skin inflammation and itching, acne, blackheads and whiteheads, pigmentation and rough skin.

Medically reviewed by Dr. Balaji Krishnan, MBBS · Updated September 2026

₹217₹10.83 per ml
Licensed pharmacyPharmacist-verified orderDelivered across India

Key details

Salt: Clobetasol (0.05%w/w) + Salicylic Acid (3.5%w/w)
Available variants: lotion lotion 20ML
Best price: ₹217 (₹10.83 per ml)
Prescription: Required
Manufacturer: ZYDUS HEALTHCARE PHARMA

Ordering notes

Standard delivery across India. No same-day delivery nationally.
Chennai express delivery is possible and chargeable. Learn more
Returns & refunds: orders can be cancelled before dispatch; after dispatch, returns depend on the item category. Read the full policy

Composition of Clop-S 3.5 Nano Lotion

Clop-S 3.5 Nano Lotion contains Clobetasol (0.05%w/w) + Salicylic Acid (3.5%w/w). It belongs to the Corticosteroid / calcineurin inhibitor and Retinoid / keratolytic class of medicines.

Uses of Clop-S 3.5 Nano Lotion

  • This medicine is used in the treatment of eczema
  • dermatitis
  • psoriasis
  • skin inflammation and itching
  • acne
  • blackheads and whiteheads
  • pigmentation and rough skin.

Key benefits

  • Rapid relief of itching and inflammation
  • Acts where it is applied
  • Clears and prevents acne
  • Improves skin texture and marks over time

How Clop-S 3.5 Nano Lotion works

This medicine combines 2 active ingredients: Clobetasol and Salicylic Acid. Clobetasol damps down the inflammation in the skin, which relieves redness, swelling and itching. Salicylic Acid unblocks the pores and speeds up the turnover of skin cells, so fewer spots form.

How to take Clop-S 3.5 Nano Lotion

Clean and dry the affected area, then apply a thin layer and rub it in gently. Wash your hands before and after use, unless your hands are the area being treated. This is for use on the skin only — do not swallow it. Follow the dose and the duration written on your prescription.

Take it exactly as your doctor prescribed. Do not change the dose or stop early on your own.

Missed dose and overdose

If you miss a dose

Apply it as soon as you remember. If it is nearly time for the next application, skip the missed one — applying extra does not make up for it.

If you take too much

An overdose of this medicine can suppress the body's own steroid production when it is used for a long time over large areas, especially in children. It can cause severe irritation when far too much cream is applied; an oral retinoid taken in excess can cause headache, vomiting and liver injury. Do not wait for symptoms to appear — go to the nearest emergency department and take the pack or strip with you.

Side effects of Clop-S 3.5 Nano Lotion

Most side effects of Clop-S are mild and settle as the body adjusts. Reported side effects include:

  • Burning or stinging
  • Thinning of the skin
  • Stretch marks
  • Acne
  • Change in skin colour
  • Dryness
  • Peeling
  • Redness
  • Increased sensitivity to sunlight

Stop the medicine and seek help immediately for a rash, swelling of the face or lips, wheezing or difficulty breathing. Tell your doctor about any side effect that persists or worries you.

Safety advice for Clop-S 3.5 Nano Lotion

PregnancyNot recommended in pregnancy — it may harm the developing baby. Tell your doctor at once if you are or might be pregnant.
BreastfeedingNot recommended while breastfeeding.
AlcoholAlcohol may worsen the side effects of this medicine. Limit it.
DrivingNot expected to affect your ability to drive.
KidneyUse with caution if you have kidney disease — your doctor may adjust the dose or monitor your kidney function.
LiverConsult your doctor if you have liver disease.
Habit formingNo

Warnings and precautions

Use it only on the area and for the number of days your doctor specified. Potent steroid creams thin the skin permanently when used for too long. Never use a potent steroid cream on the face, the groin or the underarms unless your doctor has specifically told you to — the skin there is thin and absorbs much more. Do not use it on an infection. A steroid on ringworm, impetigo or herpes makes the infection worse while hiding it. Do not use leftover cream on a new rash, and never pass it to someone else. Stop and see your doctor if the area becomes more painful, weepy or crusted. Acne often looks worse for the first two to four weeks before it improves. This is expected — do not stop. Use sunscreen every day. These medicines make the skin burn much more easily. Oral isotretinoin must never be taken in pregnancy — it causes severe birth defects. Reliable contraception and the pregnancy tests your dermatologist requires are essential before, during and after the course. Start with alternate nights and build up, and do not use more than a pea-sized amount for the whole face. Do not combine several strong acne actives at once without advice — the irritation compounds.

Do not take Clop-S if

Not for anyone with a known allergy to this medicine or to any ingredient in the pack. Not for untreated bacterial, fungal or viral skin infections. Not for use in or around the eyes. Oral retinoids are absolutely contraindicated in pregnancy and in anyone who might become pregnant without a pregnancy prevention programme. Topical retinoids are avoided in pregnancy.

Interactions with other medicines

No significant interactions are expected from preparations used on the skin. Do not combine with other peeling agents or with waxing and harsh scrubs. Oral retinoids must not be combined with tetracycline antibiotics.

How to store Clop-S 3.5 Nano Lotion

Store below 30°C, away from direct sunlight. Close the cap tightly after each use. Keep out of the reach of children.

Expert advice for Clop-S 3.5 Nano Lotion

Apply a thin layer — a fingertip's worth covers an area about the size of two adult palms. Use a plain moisturiser generously alongside it; that is what keeps eczema away between flares. Ask your doctor for a written plan of how long to use it and when to step down. Apply retinoids at night to clean, dry skin, and moisturise afterwards. Give it at least eight to twelve weeks before judging whether it works. Do not pick or squeeze spots — that is what leaves scars.

Manufacturer and class

Manufacturer:
ZYDUS HEALTHCARE PHARMA
Therapeutic class:
Topical corticosteroid and Anti-acne agent
Drug class:
Corticosteroid / calcineurin inhibitor and Retinoid / keratolytic

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Clop-S 3.5 Nano Lotion FAQs

What is Clop-S 3.5 Nano Lotion used for?
Clop-S 3.5 Nano Lotion is commonly used for This medicine is used in the treatment of eczema, dermatitis, psoriasis, skin inflammation and itching, acne, blackheads and whiteheads, pigmentation and rough skin. Always follow your doctor's advice, this information is for educational purposes and not a substitute for professional medical guidance.
What is the salt in Clop-S 3.5 Nano Lotion?
Clop-S 3.5 Nano Lotion contains Clobetasol (0.05%w/w) + Salicylic Acid (3.5%w/w). If you are allergic to any of these active ingredients or excipients, do not take this medicine and speak to your doctor first.
How should I take Clop-S 3.5 Nano Lotion?
Clean and dry the affected area, then apply a thin layer and rub it in gently. Take it exactly as prescribed; do not change the dose or stop early without talking to your doctor.
How does Clop-S 3.5 Nano Lotion work?
This medicine combines 2 active ingredients: Clobetasol and Salicylic Acid.
Is Clop-S 3.5 Nano Lotion a prescription medicine?
Yes. Clop-S 3.5 Nano Lotion is a prescription-only (Rx) medicine. Upload a valid prescription from a registered medical practitioner during checkout. We cannot dispense it without a valid Rx.
What are the common side effects of Clop-S 3.5 Nano Lotion?
The side effects reported most often with Clop-S are Burning or stinging, Thinning of the skin, Stretch marks, Acne, Change in skin colour. Most are mild and settle as the body adjusts; tell your doctor if any of them persist or worry you, and stop the medicine and seek help at once for a rash, swelling of the face or lips, or difficulty breathing.
Can Clop-S 3.5 Nano Lotion be taken during pregnancy?
Not recommended in pregnancy — it may harm the developing baby. Always tell your doctor if you are pregnant, planning a pregnancy or breastfeeding before starting Clop-S.
Can I drink alcohol while taking Clop-S 3.5 Nano Lotion?
Alcohol may worsen the side effects of this medicine.
What if I miss a dose of Clop-S 3.5 Nano Lotion?
Apply it as soon as you remember.
Is Clop-S 3.5 Nano Lotion habit forming?
No. Clop-S 3.5 Nano Lotion is not known to be habit forming when taken as prescribed.
How much does Clop-S 3.5 Nano Lotion cost on PingMeDoc Pharmacy?
Clop-S 3.5 Nano Lotion starts at ₹217 on PingMeDoc Pharmacy. Available in lotion lotion 20ML. Final price is confirmed at checkout and may vary by variant and location.
Who manufactures Clop-S 3.5 Nano Lotion?
Clop-S 3.5 Nano Lotion is manufactured by ZYDUS HEALTHCARE PHARMA. PingMeDoc Pharmacy sources medicines only from licensed manufacturers and distributors.
How is Clop-S 3.5 Nano Lotion delivered?
Clop-S 3.5 Nano Lotion is delivered across India via our licensed pharmacy partners. Standard delivery timelines are confirmed at checkout. Chennai customers can opt for chargeable same-city express delivery.

Clop-S 3.5 Nano Lotion, Quick facts

Salt
Clobetasol (0.05%w/w) + Salicylic Acid (3.5%w/w)
Form
lotion
Best price
₹217 (₹10.83 per ml)
Prescription
Required (Rx)
Brand
ZYDUS HEALTHCARE PHARMA
Manufacturer
ZYDUS HEALTHCARE PHARMA
Therapeutic class
Topical corticosteroid and Anti-acne agent
Drug class
Corticosteroid / calcineurin inhibitor and Retinoid / keratolytic
Habit forming
No
Variants
lotion lotion 20ML
Delivery
Standard across India

References

The information on Clop-S 3.5 Nano Lotion is compiled from the manufacturer's prescribing information and the sources below, and is reviewed by a registered medical practitioner. It does not replace advice from your own doctor.

  1. PingMeDoc clinical monograph library — compiled from Indian package inserts, the Indian Pharmacopoeia
  2. CDSCO schedules and standard pharmacology references. Reviewed for patient readability. This is general information, not a substitute for your doctor's advice.
  3. Central Drugs Standard Control Organisation (CDSCO), Ministry of Health & Family Welfare, Government of India, approved drug and schedule listings.
  4. National List of Essential Medicines (NLEM) 2022, Government of India.
  5. Manufacturer's package insert / prescribing information for Clop-S 3.5 Nano Lotion.
  6. World Health Organization, ATC/DDD classification and Model Formulary for the active ingredient.

Next steps

Safety disclaimer

Product information is for general awareness and does not replace professional medical advice. Always follow a clinician's guidance and upload a valid prescription when required.