Gabastone Nt.

Composition of Gabastone Nt.

Gabastone Nt. contains Gabapentin (400mg) + Nortriptyline (10mg/gm). It belongs to the Gabapentinoid (antiepileptic) + Tricyclic antidepressant (TCA) class of medicines.

Uses of Gabastone Nt.

• Neuropathic (nerve) pain such as diabetic neuropathy
• post-herpetic neuralgia
• radiculopathy/sciatica-related neuropathic pain
• and other chronic nerve pain conditions as prescribed.

Key benefits

• Relieves neuropathic (nerve) pain
• Reduces burning/tingling sensations
• Improves sleep disturbed by pain
• Helpful in chronic nerve pain conditions

How Gabastone Nt. works

Gabapentin reduces abnormal nerve signalling by binding to the alpha-2-delta subunit of voltage-gated calcium channels in the CNS, thereby decreasing release of excitatory neurotransmitters. Nortriptyline (a tricyclic antidepressant) increases levels of norepinephrine and serotonin in pain pathways and also modulates sodium channels, enhancing pain control.

How to take Gabastone Nt.

Take by mouth exactly as prescribed, usually once daily at night or in divided doses. Can be taken with or without food; taking after food may reduce stomach upset. Swallow whole with water; do not stop suddenly without medical advice.

Take it exactly as your doctor prescribed. Do not change the dose or stop early on your own.

Missed dose and overdose

If you miss a dose

Take the missed dose of Gabastone Nt. as soon as you remember. If it is almost time for the next dose, skip the missed one and carry on with the usual schedule. Do not take two doses together to make up for a missed dose.

If you take too much

Taking more Gabastone Nt. than prescribed can be harmful. If you suspect an overdose, contact a doctor or go to the nearest emergency department at once, and carry the pack or strip with you. In India the emergency number is 112.

Side effects of Gabastone Nt.

Most side effects of Gabastone Nt. are mild and settle as the body adjusts. Reported side effects include:

• Drowsiness
• dizziness
• dry mouth
• constipation
• blurred vision
• nausea
• fatigue
• weight gain
• peripheral edema (swelling)
• difficulty concentrating

Stop the medicine and seek help immediately for a rash, swelling of the face or lips, wheezing or difficulty breathing. Tell your doctor about any side effect that persists or worries you.

Safety advice for Gabastone Nt.

Warnings and precautions

May cause sleepiness/dizziness—avoid driving or operating machinery until you know its effects. Do not stop abruptly (risk of withdrawal symptoms and worsening pain/seizures with gabapentin). Use with caution in elderly, kidney disease (dose adjustment for gabapentin), glaucoma, urinary retention/prostate enlargement, heart disease/arrhythmias, and history of bipolar disorder or suicidal thoughts (monitor mood/behavior). Nortriptyline can cause orthostatic hypotension and may worsen angle-closure glaucoma. Seek urgent help for suicidal ideation, severe rash/allergy, breathing difficulty, or severe swelling.

Interactions with other medicines

Alcohol and other CNS depressants (opioids, benzodiazepines, sedating antihistamines) increase drowsiness/respiratory depression; MAO inhibitors (contraindicated with nortriptyline); SSRIs/SNRIs and other serotonergic drugs (risk of serotonin syndrome); medicines that prolong QT interval/antiarrhythmics (additive cardiac risk with nortriptyline); anticholinergics (increased dry mouth/constipation/urinary retention); gabapentin absorption reduced by aluminum/magnesium antacids (separate by at least 2 hours).

How to store Gabastone Nt.

Store below 25°C in a cool, dry place, protected from light and moisture. Keep out of reach of children.

Manufacturer and class

Manufacturer:

GLADSTONE PHARMA INDIA

Therapeutic class:

Neuropathic pain / Analgesic (adjuvant)

Drug class:

Gabapentinoid (antiepileptic) + Tricyclic antidepressant (TCA)