
Amoclafix 625MG Tab
Klm Lab - Tablet - 625 mg - 10 S
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Adapalene + Clindamycin
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Nioclean-Ad is used for this medicine is used in the treatment of acne, blackheads and whiteheads, pigmentation, rough skin, bacterial infection, gut infection, skin infection and dental infection.
Medically reviewed by Dr. Balaji Krishnan, MBBS · Updated September 2026
Nioclean-Ad contains Adapalene + Clindamycin. It belongs to the Retinoid / keratolytic and Antibacterial agent class of medicines.
This medicine combines 2 active ingredients: Adapalene and Clindamycin. Adapalene unblocks the pores and speeds up the turnover of skin cells, so fewer spots form. Clindamycin kills or stops the growth of the bacteria causing your infection.
Use this medicine as your doctor has directed. Follow the dose and the duration written on your prescription.
Take it exactly as your doctor prescribed. Do not change the dose or stop early on your own.
Take it as soon as you remember. If your next dose is almost due, skip the one you missed — never take two doses together to catch up.
An overdose of this medicine can cause severe irritation when far too much cream is applied; an oral retinoid taken in excess can cause headache, vomiting and liver injury. It can cause vomiting, severe loose motions and nerve symptoms. Do not wait for symptoms to appear — go to the nearest emergency department and take the pack or strip with you.
Most side effects of Nioclean-Ad are mild and settle as the body adjusts. Reported side effects include:
Stop the medicine and seek help immediately for a rash, swelling of the face or lips, wheezing or difficulty breathing. Tell your doctor about any side effect that persists or worries you.
| Pregnancy | Not recommended in pregnancy — it may harm the developing baby. Tell your doctor at once if you are or might be pregnant. |
|---|---|
| Breastfeeding | Not recommended while breastfeeding. |
| Alcohol | Do not drink alcohol while taking this medicine. |
| Driving | May cause drowsiness or affect your concentration. Do not drive until you know how it affects you. |
| Kidney | Consult your doctor if you have kidney disease. |
| Liver | Consult your doctor if you have liver disease. |
| Habit forming | No |
Acne often looks worse for the first two to four weeks before it improves. This is expected — do not stop. Use sunscreen every day. These medicines make the skin burn much more easily. Oral isotretinoin must never be taken in pregnancy — it causes severe birth defects. Reliable contraception and the pregnancy tests your dermatologist requires are essential before, during and after the course. Start with alternate nights and build up, and do not use more than a pea-sized amount for the whole face. Do not combine several strong acne actives at once without advice — the irritation compounds. Finish the whole course even after you feel better. Do not drink any alcohol while taking metronidazole, ornidazole or tinidazole, or for the period after the course that your doctor states — the combination causes severe flushing, vomiting and a racing heart. Report severe or watery loose motions during or after the course rather than treating them yourself. Tetracyclines stain developing teeth and are avoided in young children and in pregnancy. Antibiotics do not work against colds, flu or most sore throats, which are caused by viruses.
Not for anyone with a known allergy to this medicine or to any ingredient in the pack. Oral retinoids are absolutely contraindicated in pregnancy and in anyone who might become pregnant without a pregnancy prevention programme. Topical retinoids are avoided in pregnancy.
Do not combine with other peeling agents or with waxing and harsh scrubs. Oral retinoids must not be combined with tetracycline antibiotics. Antacids, iron, zinc and calcium reduce the absorption of tetracyclines — separate them by a couple of hours. Tell your doctor if you take a blood thinner.
Store below 30°C in the original pack, away from direct sunlight and moisture. Keep out of the reach of children.
Apply retinoids at night to clean, dry skin, and moisturise afterwards. Give it at least eight to twelve weeks before judging whether it works. Do not pick or squeeze spots — that is what leaves scars. Space the doses evenly and complete the course. Take tetracyclines with a full glass of water and stay upright for half an hour afterwards. Never use a leftover antibiotic, or someone else's, for a new illness.

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The information on Nioclean-Ad is compiled from the manufacturer's prescribing information and the sources below, and is reviewed by a registered medical practitioner. It does not replace advice from your own doctor.