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Prescription requiredIcon PharmaAntidepressant

Opirest 50 mg Tablet

Opipramol (50mg)

Opirest 50 mg Tablet is used for this medicine is used in the treatment of depression, anxiety, obsessive compulsive disorder, nerve pain and migraine prevention.

Medically reviewed by Dr. Balaji Krishnan, MBBS · Updated September 2026

₹93₹9.28 per tablet
Licensed pharmacyPharmacist-verified orderDelivered across India

Key details

Salt: Opipramol (50mg)
Available variants: tablet 50 mg 10`S
Best price: ₹93 (₹9.28 per tablet)
Prescription: Required
Manufacturer: ICON PHARMA

Ordering notes

Standard delivery across India. No same-day delivery nationally.
Chennai express delivery is possible and chargeable. Learn more
Returns & refunds: orders can be cancelled before dispatch; after dispatch, returns depend on the item category. Read the full policy

Composition of Opirest 50 mg Tablet

Opirest 50 mg Tablet contains Opipramol (50mg). It belongs to the Antidepressant class of medicines.

Uses of Opirest 50 mg Tablet

  • This medicine is used in the treatment of depression
  • anxiety
  • obsessive compulsive disorder
  • nerve pain and migraine prevention.

Key benefits

  • Effective for depression and anxiety disorders
  • Also relieves nerve pain and prevents migraine
  • Usually taken once a day

How Opirest 50 mg Tablet works

Opipramol restores the balance of the chemical messengers in the brain that regulate mood, sleep and the way pain is felt.

How to take Opirest 50 mg Tablet

Swallow the tablet whole with a glass of water. Do not chew, crush or break it unless your doctor has told you to. Take it with or after food, at the same time each day. Taking it at about the same time each day helps you remember. Follow the dose and the duration written on your prescription.

Take it exactly as your doctor prescribed. Do not change the dose or stop early on your own.

Missed dose and overdose

If you miss a dose

Take it as soon as you remember. If your next dose is almost due, skip the one you missed — never take two doses together to catch up.

If you take too much

An overdose of this medicine can cause fits, dangerous heart rhythm disturbance and coma, and is particularly dangerous with the older tricyclic medicines. Do not wait for symptoms to appear — go to the nearest emergency department and take the pack or strip with you.

Side effects of Opirest 50 mg Tablet

Most side effects of Opirest are mild and settle as the body adjusts. Reported side effects include:

  • Nausea
  • Dry mouth
  • Drowsiness or difficulty sleeping
  • Headache
  • Weight change
  • Reduced sexual desire
  • Constipation

Stop the medicine and seek help immediately for a rash, swelling of the face or lips, wheezing or difficulty breathing. Tell your doctor about any side effect that persists or worries you.

Safety advice for Opirest 50 mg Tablet

PregnancyConsult your doctor before using this in pregnancy.
BreastfeedingConsult your doctor before using this while breastfeeding.
AlcoholDo not drink alcohol while taking this medicine.
DrivingMay cause drowsiness or affect your concentration. Do not drive until you know how it affects you.
KidneyUse with caution if you have kidney disease — your doctor may adjust the dose or monitor your kidney function.
LiverConsult your doctor if you have liver disease.
Habit formingNo

Warnings and precautions

These medicines take two to four weeks to begin working, and longer for the full effect. Stopping at two weeks because nothing has changed is the commonest mistake. Never stop suddenly. Abrupt withdrawal causes dizziness, electric-shock sensations, irritability and flu-like symptoms — your doctor will reduce the dose gradually. Tell your doctor or go to hospital immediately if thoughts of harming yourself appear or worsen, particularly in the first weeks or after a dose change, and especially in anyone under twenty-five. Seek urgent care for agitation with fever, shivering, a racing heart, muscle twitching or confusion, particularly if more than one medicine affecting serotonin is being taken. Side effects are usually worst in the first fortnight and then settle.

Do not take Opirest if

Not for anyone with a known allergy to this medicine or to any ingredient in the pack. Must not be combined with a monoamine oxidase inhibitor, or started within the gap your doctor specifies after one.

Interactions with other medicines

Tramadol, triptans for migraine, linezolid, St John's wort and other antidepressants can together raise serotonin dangerously. Anti-inflammatory painkillers and blood thinners increase the bleeding risk when combined with this group.

How to store Opirest 50 mg Tablet

Store below 30°C in the original pack, away from direct sunlight and moisture. Keep out of the reach of children.

Expert advice for Opirest 50 mg Tablet

Give it a fair trial of several weeks, and keep your review appointments. Take it at the same time each day — at night if it makes you drowsy, in the morning if it disturbs sleep. Talking therapy alongside medicine works better than either alone for most people.

Manufacturer and class

Manufacturer:
ICON PHARMA
Therapeutic class:
Antidepressant
Drug class:
Antidepressant

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Opirest 50 mg Tablet FAQs

What is Opirest 50 mg Tablet used for?
Opirest 50 mg Tablet is commonly used for This medicine is used in the treatment of depression, anxiety, obsessive compulsive disorder, nerve pain and migraine prevention. Always follow your doctor's advice, this information is for educational purposes and not a substitute for professional medical guidance.
What is the salt in Opirest 50 mg Tablet?
Opirest 50 mg Tablet contains Opipramol (50mg). If you are allergic to any of these active ingredients or excipients, do not take this medicine and speak to your doctor first.
How should I take Opirest 50 mg Tablet?
Swallow the tablet whole with a glass of water. Take it exactly as prescribed; do not change the dose or stop early without talking to your doctor.
How does Opirest 50 mg Tablet work?
Opipramol restores the balance of the chemical messengers in the brain that regulate mood, sleep and the way pain is felt.
Is Opirest 50 mg Tablet a prescription medicine?
Yes. Opirest 50 mg Tablet is a prescription-only (Rx) medicine. Upload a valid prescription from a registered medical practitioner during checkout. We cannot dispense it without a valid Rx.
What are the common side effects of Opirest 50 mg Tablet?
The side effects reported most often with Opirest are Nausea, Dry mouth, Drowsiness or difficulty sleeping, Headache, Weight change. Most are mild and settle as the body adjusts; tell your doctor if any of them persist or worry you, and stop the medicine and seek help at once for a rash, swelling of the face or lips, or difficulty breathing.
Can Opirest 50 mg Tablet be taken during pregnancy?
Consult your doctor before using this in pregnancy. Always tell your doctor if you are pregnant, planning a pregnancy or breastfeeding before starting Opirest.
Can I drink alcohol while taking Opirest 50 mg Tablet?
Do not drink alcohol while taking this medicine.
What if I miss a dose of Opirest 50 mg Tablet?
Take it as soon as you remember.
Is Opirest 50 mg Tablet habit forming?
No. Opirest 50 mg Tablet is not known to be habit forming when taken as prescribed.
How much does Opirest 50 mg Tablet cost on PingMeDoc Pharmacy?
Opirest 50 mg Tablet starts at ₹93 on PingMeDoc Pharmacy. Available in tablet 50 mg 10`S. Final price is confirmed at checkout and may vary by variant and location.
Who manufactures Opirest 50 mg Tablet?
Opirest 50 mg Tablet is manufactured by ICON PHARMA. PingMeDoc Pharmacy sources medicines only from licensed manufacturers and distributors.
How is Opirest 50 mg Tablet delivered?
Opirest 50 mg Tablet is delivered across India via our licensed pharmacy partners. Standard delivery timelines are confirmed at checkout. Chennai customers can opt for chargeable same-city express delivery.

Opirest 50 mg Tablet, Quick facts

Salt
Opipramol (50mg)
Form
tablet
Best price
₹93 (₹9.28 per tablet)
Prescription
Required (Rx)
Brand
ICON PHARMA
Manufacturer
ICON PHARMA
Therapeutic class
Antidepressant
Drug class
Antidepressant
Habit forming
No
Variants
tablet 50 mg 10`S
Delivery
Standard across India

References

The information on Opirest 50 mg Tablet is compiled from the manufacturer's prescribing information and the sources below, and is reviewed by a registered medical practitioner. It does not replace advice from your own doctor.

  1. PingMeDoc clinical monograph library — compiled from Indian package inserts, the Indian Pharmacopoeia
  2. CDSCO schedules and standard pharmacology references. Reviewed for patient readability. This is general information, not a substitute for your doctor's advice.
  3. Central Drugs Standard Control Organisation (CDSCO), Ministry of Health & Family Welfare, Government of India, approved drug and schedule listings.
  4. National List of Essential Medicines (NLEM) 2022, Government of India.
  5. Manufacturer's package insert / prescribing information for Opirest 50 mg Tablet.
  6. World Health Organization, ATC/DDD classification and Model Formulary for the active ingredient.

Next steps

Safety disclaimer

Product information is for general awareness and does not replace professional medical advice. Always follow a clinician's guidance and upload a valid prescription when required.