
Adaple-C Gel
Wallace Pharmaceuticals Pvt Ltd - Gel - 15 G
Prescription required
Adapalene + Benzoyl Peroxide
Persol Plus Gel is used for this medicine is used in the treatment of acne, blackheads and whiteheads, pigmentation and rough skin.
Medically reviewed by Dr. Balaji Krishnan, MBBS · Updated September 2026
Persol Plus Gel contains Adapalene + Benzoyl Peroxide. It belongs to the Retinoid / keratolytic class of medicines.
This medicine combines 2 active ingredients: Adapalene and Benzoyl Peroxide. Adapalene unblocks the pores and speeds up the turnover of skin cells, so fewer spots form. Benzoyl Peroxide unblocks the pores and speeds up the turnover of skin cells, so fewer spots form.
Clean and dry the affected area, then apply a thin layer and rub it in gently. Wash your hands before and after use, unless your hands are the area being treated. This is for use on the skin only — do not swallow it. Follow the dose and the duration written on your prescription.
Take it exactly as your doctor prescribed. Do not change the dose or stop early on your own.
Apply it as soon as you remember. If it is nearly time for the next application, skip the missed one — applying extra does not make up for it.
An overdose of this medicine can cause severe irritation when far too much cream is applied; an oral retinoid taken in excess can cause headache, vomiting and liver injury. Do not wait for symptoms to appear — go to the nearest emergency department and take the pack or strip with you.
Most side effects of Persol Plus are mild and settle as the body adjusts. Reported side effects include:
Stop the medicine and seek help immediately for a rash, swelling of the face or lips, wheezing or difficulty breathing. Tell your doctor about any side effect that persists or worries you.
| Pregnancy | Not recommended in pregnancy — it may harm the developing baby. Tell your doctor at once if you are or might be pregnant. |
|---|---|
| Breastfeeding | Not recommended while breastfeeding. |
| Alcohol | Alcohol may worsen the side effects of this medicine. Limit it. |
| Driving | Not expected to affect your ability to drive. |
| Kidney | Use with caution if you have kidney disease — your doctor may adjust the dose or monitor your kidney function. |
| Liver | Consult your doctor if you have liver disease. |
| Habit forming | No |
Acne often looks worse for the first two to four weeks before it improves. This is expected — do not stop. Use sunscreen every day. These medicines make the skin burn much more easily. Oral isotretinoin must never be taken in pregnancy — it causes severe birth defects. Reliable contraception and the pregnancy tests your dermatologist requires are essential before, during and after the course. Start with alternate nights and build up, and do not use more than a pea-sized amount for the whole face. Do not combine several strong acne actives at once without advice — the irritation compounds.
Not for anyone with a known allergy to this medicine or to any ingredient in the pack. Oral retinoids are absolutely contraindicated in pregnancy and in anyone who might become pregnant without a pregnancy prevention programme. Topical retinoids are avoided in pregnancy.
Do not combine with other peeling agents or with waxing and harsh scrubs. Oral retinoids must not be combined with tetracycline antibiotics.
Store below 30°C, away from direct sunlight. Close the cap tightly after each use. Keep out of the reach of children.
Apply retinoids at night to clean, dry skin, and moisturise afterwards. Give it at least eight to twelve weeks before judging whether it works. Do not pick or squeeze spots — that is what leaves scars.

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The information on Persol Plus Gel is compiled from the manufacturer's prescribing information and the sources below, and is reviewed by a registered medical practitioner. It does not replace advice from your own doctor.