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Dapoxetine 50 mg + Tadalafil 20 mg (capsule)
Preloxetin 50/20 mg Capsule is used for treatment of premature ejaculation with erectile dysfunction in adult men, helps improve ejaculatory control and erectile function.
Medically reviewed by Dr. Balaji Krishnan, MBBS · Updated September 2026
Preloxetin 50/20 mg Capsule contains Dapoxetine 50 mg + Tadalafil 20 mg (capsule). It belongs to the PDE-5 inhibitor + SSRI (dapoxetine) class of medicines.
Dapoxetine is a short-acting SSRI that increases serotonin activity in the nervous system, improving control over ejaculation and increasing time to ejaculation. Tadalafil is a PDE-5 inhibitor that increases blood flow to the penis during sexual stimulation, helping achieve and maintain an erection.
Take exactly as prescribed by a doctor. Generally taken orally with water 1–3 hours before sexual activity; do not take more than once in 24 hours. Can be taken with or without food; avoid heavy/fatty meals if advised as they may delay effect.
Take it exactly as your doctor prescribed. Do not change the dose or stop early on your own.
Take it as soon as you remember. If your next dose is almost due, skip the one you missed — never take two doses together to catch up.
An overdose of this medicine may be harmful — seek medical advice immediately. Do not wait for symptoms to appear — go to the nearest emergency department and take the pack or strip with you.
Most side effects of Preloxetin 50/20 mg are mild and settle as the body adjusts. Reported side effects include:
Stop the medicine and seek help immediately for a rash, swelling of the face or lips, wheezing or difficulty breathing. Tell your doctor about any side effect that persists or worries you.
| Pregnancy | Not recommended (product intended for adult men only) |
|---|---|
| Breastfeeding | Consult your doctor before using this while breastfeeding. |
| Alcohol | Avoid (may increase dizziness, low blood pressure and fainting risk) |
| Driving | May cause drowsiness or affect your concentration. Do not drive until you know how it affects you. |
| Kidney | Use with caution if you have kidney disease — your doctor may adjust the dose or monitor your kidney function. |
| Liver | Use with caution if you have liver disease — your doctor may adjust the dose or monitor your liver function. |
| Habit forming | No |
For adult men only. Do not use with nitrates (for chest pain) or riociguat due to dangerous fall in blood pressure. Use caution in heart disease, history of fainting/low blood pressure, liver or kidney impairment, bleeding disorders, seizures, glaucoma, or penile deformity. May cause dizziness/syncope—avoid driving/operating machinery after dosing. Seek urgent help for chest pain, severe dizziness/fainting, allergic reaction, sudden vision/hearing loss, or erection lasting >4 hours (priapism). Not recommended in women and children.
Not for anyone with a known allergy to this medicine or to any ingredient in the pack. Your doctor will confirm this medicine is suitable for you.
Nitrates (nitroglycerin, isosorbide), riociguat, alpha-blockers and other antihypertensives (additive hypotension), other PDE-5 inhibitors, strong CYP3A4 inhibitors (ketoconazole, itraconazole, ritonavir, clarithromycin), SSRIs/SNRIs/MAOIs/triptans/linezolid (serotonin syndrome risk), thioridazine, anticoagulants/antiplatelets (bleeding risk), alcohol (increases dizziness/fainting)
Store below 25°C in a cool, dry place away from direct light and moisture. Keep in original pack and out of reach of children.
Take it at the same time each day and complete the course. Keep your follow-up appointments and any monitoring blood tests.

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The information on Preloxetin 50/20 mg Capsule is compiled from the manufacturer's prescribing information and the sources below, and is reviewed by a registered medical practitioner. It does not replace advice from your own doctor.