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Prescription requiredPulse PharmaAnalgesic and anti-inflammatory and Gastrointestinal agent

Safeguard SR Tablet

Diclofenac (100mg) + Misoprostol (200mcg)

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Safeguard SR Tablet is used for this medicine is used in the treatment of pain, inflammation, arthritis, fever, period pain, digestive problems, loose motions, restoring gut bacteria and stomach protection.

Medically reviewed by Dr. Balaji Krishnan, MBBS · Updated September 2026

Licensed pharmacyPharmacist-verified order

Key details

Salt: Diclofenac (100mg) + Misoprostol (200mcg)
Available variants: tablet 100mg + 200mcg 15`S
Best price: ₹209 (₹13.95 per tablet)
MRP: ₹220
Prescription: Required
Manufacturer: PULSE PHARMA

Ordering notes

Delivery details are shown when the medicine is back in stock.
Returns & refunds: orders can be cancelled before dispatch; after dispatch, returns depend on the item category. Read the full policy

Composition of Safeguard SR Tablet

Safeguard SR Tablet contains Diclofenac (100mg) + Misoprostol (200mcg). It belongs to the Non-steroidal anti-inflammatory drug and Gut protective / probiotic class of medicines.

Uses of Safeguard SR Tablet

  • This medicine is used in the treatment of pain
  • inflammation
  • arthritis
  • fever
  • period pain
  • digestive problems
  • loose motions
  • restoring gut bacteria and stomach protection.

Key benefits

  • Relieves pain and the swelling that causes it
  • Effective in arthritis and injury
  • Helps the gut recover after an infection or antibiotics
  • Generally well tolerated

How Safeguard SR Tablet works

This medicine combines 2 active ingredients: Diclofenac and Misoprostol. Diclofenac blocks the chemicals your body makes at a site of injury or inflammation, which reduces pain, swelling and fever. Misoprostol supports the lining and the natural bacteria of the gut, helping digestion settle back to normal.

How to take Safeguard SR Tablet

Swallow the tablet whole with a glass of water. Do not chew, crush or break it unless your doctor has told you to. Take it with or just after food. Taking it at about the same time each day helps you remember. Follow the dose and the duration written on your prescription.

Take it exactly as your doctor prescribed. Do not change the dose or stop early on your own.

Missed dose and overdose

If you miss a dose

Take it as soon as you remember. If your next dose is almost due, skip the one you missed — never take two doses together to catch up.

If you take too much

An overdose of this medicine can cause stomach bleeding, kidney failure, drowsiness and fits. It may cause bloating and loose motions. Do not wait for symptoms to appear — go to the nearest emergency department and take the pack or strip with you.

Side effects of Safeguard SR Tablet

Most side effects of Safeguard SR are mild and settle as the body adjusts. Reported side effects include:

  • Indigestion
  • Stomach pain
  • Nausea
  • Heartburn
  • Dizziness
  • Swelling of the ankles and feet
  • Bloating
  • Flatulence
  • Stomach discomfort
  • Constipation

Stop the medicine and seek help immediately for a rash, swelling of the face or lips, wheezing or difficulty breathing. Tell your doctor about any side effect that persists or worries you.

Safety advice for Safeguard SR Tablet

PregnancyNot recommended in pregnancy — it may harm the developing baby. Tell your doctor at once if you are or might be pregnant.
BreastfeedingConsult your doctor before using this while breastfeeding.
AlcoholDo not drink alcohol while taking this medicine.
DrivingMay cause drowsiness or affect your concentration. Do not drive until you know how it affects you.
KidneyConsult your doctor if you have kidney disease.
LiverConsult your doctor if you have liver disease.
Habit formingNo

Warnings and precautions

Take it with or just after food, and for the shortest time that works. Stop and seek urgent care for black or tarry stools, vomiting blood, or severe stomach pain — this group can cause bleeding from the stomach. Long or high-dose use raises the risk of heart attack, stroke and kidney injury, particularly in older people and those already at risk. Avoid if you are dehydrated or have an illness with vomiting or loose motions — the kidneys are vulnerable then. Must be avoided in the last three months of pregnancy. Loose motions with high fever, blood in the stool or severe abdominal pain need a doctor, not a home remedy. Oral rehydration salts and fluids matter more than any medicine when you have loose motions — dehydration is the real danger, especially in children and older people. Take a probiotic a couple of hours apart from an antibiotic so the antibiotic does not simply kill it. Do not use an anti-motility medicine such as loperamide if you have a fever or blood in the stool.

Do not take Safeguard SR if

Not for anyone with a known allergy to this medicine or to any ingredient in the pack. Not for people with an active stomach ulcer, severe kidney or heart failure, or asthma triggered by aspirin or anti-inflammatory painkillers. Not in the third trimester of pregnancy. Probiotics are used with caution in people whose immune system is significantly suppressed.

Interactions with other medicines

Combining with a blood thinner or aspirin sharply raises the bleeding risk. Reduces the effect of blood pressure medicines and water tablets, and together with them can harm the kidneys. Never take two anti-inflammatory painkillers at the same time. Antibiotics reduce the effect of probiotics taken at the same time.

How to store Safeguard SR Tablet

Store below 30°C in a dry place, away from direct sunlight. Some probiotic preparations ask to be refrigerated — follow the pack. Keep out of the reach of children.

Expert advice for Safeguard SR Tablet

Use the lowest dose for the shortest period. If you need a painkiller regularly, see your doctor rather than continuing on your own. Paracetamol is the safer choice for simple fever and headache. Keep up fluids and oral rehydration salts. Return to a normal diet as soon as you can manage it.

Manufacturer and class

Manufacturer:
PULSE PHARMA
Therapeutic class:
Analgesic and anti-inflammatory and Gastrointestinal agent
Drug class:
Non-steroidal anti-inflammatory drug and Gut protective / probiotic

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Safeguard SR Tablet FAQs

What is Safeguard SR Tablet used for?
Safeguard SR Tablet is commonly used for This medicine is used in the treatment of pain, inflammation, arthritis, fever, period pain, digestive problems, loose motions, restoring gut bacteria and stomach protection. Always follow your doctor's advice, this information is for educational purposes and not a substitute for professional medical guidance.
What is the salt in Safeguard SR Tablet?
Safeguard SR Tablet contains Diclofenac (100mg) + Misoprostol (200mcg). If you are allergic to any of these active ingredients or excipients, do not take this medicine and speak to your doctor first.
How should I take Safeguard SR Tablet?
Swallow the tablet whole with a glass of water. Take it exactly as prescribed; do not change the dose or stop early without talking to your doctor.
How does Safeguard SR Tablet work?
This medicine combines 2 active ingredients: Diclofenac and Misoprostol.
Is Safeguard SR Tablet a prescription medicine?
Yes. Safeguard SR Tablet is a prescription-only (Rx) medicine. Upload a valid prescription from a registered medical practitioner during checkout. We cannot dispense it without a valid Rx.
What are the common side effects of Safeguard SR Tablet?
The side effects reported most often with Safeguard SR are Indigestion, Stomach pain, Nausea, Heartburn, Dizziness. Most are mild and settle as the body adjusts; tell your doctor if any of them persist or worry you, and stop the medicine and seek help at once for a rash, swelling of the face or lips, or difficulty breathing.
Can Safeguard SR Tablet be taken during pregnancy?
Not recommended in pregnancy — it may harm the developing baby. Always tell your doctor if you are pregnant, planning a pregnancy or breastfeeding before starting Safeguard SR.
Can I drink alcohol while taking Safeguard SR Tablet?
Do not drink alcohol while taking this medicine.
What if I miss a dose of Safeguard SR Tablet?
Take it as soon as you remember.
Is Safeguard SR Tablet habit forming?
No. Safeguard SR Tablet is not known to be habit forming when taken as prescribed.
How much does Safeguard SR Tablet cost on PingMeDoc Pharmacy?
Safeguard SR Tablet starts at ₹209 (MRP ₹220) on PingMeDoc Pharmacy. Available in tablet 100mg + 200mcg 15`S. Final price is confirmed at checkout and may vary by variant and location.
Who manufactures Safeguard SR Tablet?
Safeguard SR Tablet is manufactured by PULSE PHARMA. PingMeDoc Pharmacy sources medicines only from licensed manufacturers and distributors.
How is Safeguard SR Tablet delivered?
Safeguard SR Tablet is delivered across India via our licensed pharmacy partners. Standard delivery timelines are confirmed at checkout. Chennai customers can opt for chargeable same-city express delivery.

Safeguard SR Tablet, Quick facts

Salt
Diclofenac (100mg) + Misoprostol (200mcg)
Form
tablet
Best price
₹209 (₹13.95 per tablet)
MRP
₹220
Prescription
Required (Rx)
Schedule
Schedule H
Brand
PULSE PHARMA
Manufacturer
PULSE PHARMA
Therapeutic class
Analgesic and anti-inflammatory and Gastrointestinal agent
Drug class
Non-steroidal anti-inflammatory drug and Gut protective / probiotic
Habit forming
No
Variants
tablet 100mg + 200mcg 15`S
Delivery
Standard across India

References

The information on Safeguard SR Tablet is compiled from the manufacturer's prescribing information and the sources below, and is reviewed by a registered medical practitioner. It does not replace advice from your own doctor.

  1. PingMeDoc clinical monograph library — compiled from Indian package inserts, the Indian Pharmacopoeia
  2. CDSCO schedules and standard pharmacology references. Reviewed for patient readability. This is general information, not a substitute for your doctor's advice.
  3. Central Drugs Standard Control Organisation (CDSCO), Ministry of Health & Family Welfare, Government of India, approved drug and schedule listings.
  4. National List of Essential Medicines (NLEM) 2022, Government of India.
  5. Manufacturer's package insert / prescribing information for Safeguard SR Tablet.
  6. World Health Organization, ATC/DDD classification and Model Formulary for the active ingredient.

Next steps

Safety disclaimer

Product information is for general awareness and does not replace professional medical advice. Always follow a clinician's guidance and upload a valid prescription when required.