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Prescription requiredLupin LabPAIN ANALGESICS

Signoheal Tablet

Bromelain (90mg) + Trypsin (48mg) + Rutoside (100mg)

Currently out of stock

Same composition, in stock now. Check with your doctor or pharmacist before you switch.

  • Mitime Tablet₹175View
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Signoheal Tablet is used for pain relief.

Medically reviewed by Dr. Balaji Krishnan, MBBS · Updated September 2026

Licensed pharmacyPharmacist-verified order

Key details

Salt: Bromelain (90mg) + Trypsin (48mg) + Rutoside (100mg)
Available variants: tablet 90mg + 48mg + 100mg 10`S
Best price: ₹159 (₹15.91 per tablet)
MRP: ₹167
Prescription: Required
Manufacturer: LUPIN LAB

Ordering notes

Delivery details are shown when the medicine is back in stock.
Returns & refunds: orders can be cancelled before dispatch; after dispatch, returns depend on the item category. Read the full policy

Composition of Signoheal Tablet

Signoheal Tablet contains Bromelain (90mg) + Trypsin (48mg) + Rutoside (100mg). It belongs to the Enzyme / disease-modifying anti-rheumatic agent class of medicines.

Uses of Signoheal Tablet

Pain relief

Key benefits

  • In Pain relief Signoheal Tablet is a combination of medicines used for relief of pain
  • inflammation
  • and swelling in conditions that may occur due to trauma
  • surgery or everyday life. It may also be used to provide relief in degenerative and inflammatory conditions that affect muscles and joints such as rheumatoid arthritis and osteoarthritis. It promotes speedy recovery due to its anti-inflammatory and antioxidant properties. Take it as it is prescribed to get the most benefit. This will help you to go about your daily activities more easily and have a better
  • more active
  • quality of life.

How Signoheal Tablet works

Signoheal Tablet is a combination of two enzymes (Bromelain, Trypsin) and an antioxidant (Rutoside). The enzymes work by increasing the blood supply to the affected area and helping the body produce substances that fight pain and swelling. The antioxidant protects the body from damage by chemicals (free radicals) and further reduces swelling.

How to take Signoheal Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Signoheal Tablet may be taken with or without food.

Take it exactly as your doctor prescribed. Do not change the dose or stop early on your own.

Missed dose and overdose

If you miss a dose

If you miss a dose of Signoheal Tablet, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.

If you take too much

An overdose of this medicine can seriously suppress the bone marrow and damage the liver. Do not wait for symptoms to appear — go to the nearest emergency department and take the pack or strip with you.

Side effects of Signoheal Tablet

Most side effects of Signoheal are mild and settle as the body adjusts. Reported side effects include:

  • Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Stop the medicine and seek help immediately for a rash, swelling of the face or lips, wheezing or difficulty breathing. Tell your doctor about any side effect that persists or worries you.

Safety advice for Signoheal Tablet

PregnancyPregnancy CONSULT YOUR DOCTOR
BreastfeedingBreast feeding CONSULT YOUR DOCTOR
AlcoholAlcohol CONSULT YOUR DOCTOR
DrivingDriving CONSULT YOUR DOCTOR
KidneyKidney CAUTION
LiverLiver CAUTION
Habit formingNo

Warnings and precautions

Medicines that suppress the immune system need regular blood tests — do not miss them. Report fever, sore throat, mouth ulcers or unusual bruising promptly if you are on an immune-suppressing medicine. Tell your doctor about any infection, and before any vaccination. Methotrexate for arthritis is taken ONCE A WEEK. Taking it daily by mistake is dangerous — check the day on your pack.

Do not take Signoheal if

Not for anyone with a known allergy to this medicine or to any ingredient in the pack. Not for people with an active serious infection, or with severe liver or bone-marrow disease. Several of these medicines must not be used in pregnancy.

Interactions with other medicines

Tell your doctor about all other medicines, especially anti-inflammatory painkillers and antibiotics. Live vaccines are generally avoided while on immune-suppressing treatment.

How to store Signoheal Tablet

Store below 30°C in the original pack, away from direct sunlight and moisture. Keep out of the reach of children.

Expert advice for Signoheal Tablet

Take it with plenty of fluids, an hour before or two hours after a meal. It may increase the severity of your condition at the start of treatment. Continue using it as prescribed by your doctor. It may cause dizziness and blurred vision. Don't drive or do anything requiring concentration until you know how it affects you. It may change the color, consistency, and odor of your stool. This is harmless. Inform your doctor if this bothers you.

Manufacturer and class

Manufacturer:
LUPIN LAB
Therapeutic class:
PAIN ANALGESICS
Drug class:
Enzyme / disease-modifying anti-rheumatic agent

Substitutes for Signoheal Tablet

Medicines with the same active ingredient (Bromelain (90mg) + Trypsin (48mg) + Rutoside (100mg)). Ask your doctor or pharmacist before switching brands.

MedicinePackPricevs Signoheal Tablet
Mitime TabletCOGNYZON PHARMACEUTICALStablet · 10`S₹17510% more
Xepsin Br TabletXEMEX PHARMAtablet · 10`S₹17611% more
Usen Dr TabletMNW LIFE SCIENCEStablet · 10`S₹18315% more
Trimo Br TabletBIOCEUTICStablet · 10`S₹20025% more
Rouzyme TabletROUCHER BIOSCIENCES PVT LTDtablet · 10`S₹21737% more
Zymoflam TabletARISTO PHARMACEUTICALS PVT LTDtablet · 10`S₹27673% more
Zymogesic TabletMEYER ORGANICS PVT LTDtablet · 10`S₹30290% more
Enzomac PlusMacleods Pharmaceuticals Pvt Ltd10`S₹30391% more
Enzomac ForteMacleods Pharmaceuticals Pvt Ltd10`S₹517225% more
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Signoheal Tablet FAQs

What is Signoheal Tablet used for?
Signoheal Tablet is commonly used for Pain relief. Always follow your doctor's advice, this information is for educational purposes and not a substitute for professional medical guidance.
What is the salt in Signoheal Tablet?
Signoheal Tablet contains Bromelain (90mg) + Trypsin (48mg) + Rutoside (100mg). If you are allergic to any of these active ingredients or excipients, do not take this medicine and speak to your doctor first.
How should I take Signoheal Tablet?
Take this medicine in the dose and duration as advised by your doctor. Take it exactly as prescribed; do not change the dose or stop early without talking to your doctor.
How does Signoheal Tablet work?
Signoheal Tablet is a combination of two enzymes (Bromelain, Trypsin) and an antioxidant (Rutoside).
Is Signoheal Tablet a prescription medicine?
Yes. Signoheal Tablet is a prescription-only (Rx) medicine. Upload a valid prescription from a registered medical practitioner during checkout. We cannot dispense it without a valid Rx.
What are the common side effects of Signoheal Tablet?
The side effects reported most often with Signoheal are Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them. Most are mild and settle as the body adjusts; tell your doctor if any of them persist or worry you, and stop the medicine and seek help at once for a rash, swelling of the face or lips, or difficulty breathing.
Can Signoheal Tablet be taken during pregnancy?
Pregnancy CONSULT YOUR DOCTOR Always tell your doctor if you are pregnant, planning a pregnancy or breastfeeding before starting Signoheal.
Can I drink alcohol while taking Signoheal Tablet?
Alcohol CONSULT YOUR DOCTOR
What if I miss a dose of Signoheal Tablet?
If you miss a dose of Signoheal Tablet, take it as soon as possible.
Is Signoheal Tablet habit forming?
No. Signoheal Tablet is not known to be habit forming when taken as prescribed.
How much does Signoheal Tablet cost on PingMeDoc Pharmacy?
Signoheal Tablet starts at ₹159 (MRP ₹167) on PingMeDoc Pharmacy. Available in tablet 90mg + 48mg + 100mg 10`S. Final price is confirmed at checkout and may vary by variant and location.
Who manufactures Signoheal Tablet?
Signoheal Tablet is manufactured by LUPIN LAB. PingMeDoc Pharmacy sources medicines only from licensed manufacturers and distributors.
How is Signoheal Tablet delivered?
Signoheal Tablet is delivered across India via our licensed pharmacy partners. Standard delivery timelines are confirmed at checkout. Chennai customers can opt for chargeable same-city express delivery.

Signoheal Tablet, Quick facts

Salt
Bromelain (90mg) + Trypsin (48mg) + Rutoside (100mg)
Form
tablet
Best price
₹159 (₹15.91 per tablet)
MRP
₹167
Prescription
Required (Rx)
Brand
LUPIN LAB
Manufacturer
LUPIN LAB
Therapeutic class
PAIN ANALGESICS
Drug class
Enzyme / disease-modifying anti-rheumatic agent
Habit forming
No
Variants
tablet 90mg + 48mg + 100mg 10`S
Delivery
Standard across India

References

The information on Signoheal Tablet is compiled from the manufacturer's prescribing information and the sources below, and is reviewed by a registered medical practitioner. It does not replace advice from your own doctor.

  1. PingMeDoc clinical monograph library — compiled from Indian package inserts, the Indian Pharmacopoeia
  2. CDSCO schedules and standard pharmacology references. Reviewed for patient readability. This is general information, not a substitute for your doctor's advice.
  3. Central Drugs Standard Control Organisation (CDSCO), Ministry of Health & Family Welfare, Government of India, approved drug and schedule listings.
  4. National List of Essential Medicines (NLEM) 2022, Government of India.
  5. Manufacturer's package insert / prescribing information for Signoheal Tablet.
  6. World Health Organization, ATC/DDD classification and Model Formulary for the active ingredient.

Next steps

Safety disclaimer

Product information is for general awareness and does not replace professional medical advice. Always follow a clinician's guidance and upload a valid prescription when required.