Trigaine Solution

Composition of Trigaine Solution

Trigaine Solution contains Minoxidil (2%w/v) + Azelaic Acid (1.5%w/v) + Tretinoin (0.025%w/v). It belongs to the Hair growth stimulant / anti-dandruff agent and Retinoid / keratolytic class of medicines.

Uses of Trigaine Solution

Trigaine Solution is used in the treatment of hair loss.

Key benefits

• Slows hair loss and can regrow hair
• Controls dandruff and scalp flaking
• Clears and prevents acne
• Improves skin texture and marks over time

How Trigaine Solution works

Trigaine Solution is a combination of three medicines: Minoxidil, Azelaic Acid and Tretinoin which treat hair loss. Minoxidil is a vasodilator, meaning it widens the blood vessels and provides better blood flow to the hair follicles. This prevents hair loss and stimulates re-growth resulting in longer, thicker and increased numbers of hair. Azelaic Acid is a naturally occurring acid which reduces the levels of dihydrotestostrone, a hormone that triggers hair loss. Tretinoin is a form of vitamin A. It works by promoting the growth of hair follicles on the scalp.

How to take Trigaine Solution

Use this medicine in the dose and duration as advised by your doctor. Check the label for directions before use.

Take it exactly as your doctor prescribed. Do not change the dose or stop early on your own.

Missed dose and overdose

If you miss a dose

Take it as soon as you remember. If your next dose is almost due, skip the one you missed — never take two doses together to catch up.

If you take too much

An overdose of this medicine can cause a fall in blood pressure and a racing heart when far too much is applied to the skin. It can cause severe irritation when far too much cream is applied; an oral retinoid taken in excess can cause headache, vomiting and liver injury. Do not wait for symptoms to appear — go to the nearest emergency department and take the pack or strip with you.

Side effects of Trigaine Solution

Most side effects of Trigaine are mild and settle as the body adjusts. Reported side effects include:

• Application site irritation Itching Headache

Stop the medicine and seek help immediately for a rash, swelling of the face or lips, wheezing or difficulty breathing. Tell your doctor about any side effect that persists or worries you.

Safety advice for Trigaine Solution

Warnings and precautions

Topical minoxidil causes a burst of shedding in the first two to eight weeks. This is the old hair making way for new — it is expected, not a failure. Results take three to six months, and stop when you stop. This is a continuing treatment, not a cure. Finasteride must not be handled or taken by anyone who is pregnant or could become pregnant — it causes birth defects. Do not let a pregnant person handle broken or crushed tablets. Apply topical treatments to a dry scalp, not to hair, and wash your hands afterwards. Tell your doctor about any chest pain, dizziness, rapid heartbeat or sudden weight gain with minoxidil. Acne often looks worse for the first two to four weeks before it improves. This is expected — do not stop. Use sunscreen every day. These medicines make the skin burn much more easily. Oral isotretinoin must never be taken in pregnancy — it causes severe birth defects. Reliable contraception and the pregnancy tests your dermatologist requires are essential before, during and after the course. Start with alternate nights and build up, and do not use more than a pea-sized amount for the whole face. Do not combine several strong acne actives at once without advice — the irritation compounds.

Do not take Trigaine if

Not for anyone with a known allergy to this medicine or to any ingredient in the pack. Not for use on inflamed, broken or sunburnt scalp. Oral retinoids are absolutely contraindicated in pregnancy and in anyone who might become pregnant without a pregnancy prevention programme. Topical retinoids are avoided in pregnancy.

Interactions with other medicines

Avoid applying other scalp products at the same time of day unless advised. Do not combine with other peeling agents or with waxing and harsh scrubs. Oral retinoids must not be combined with tetracycline antibiotics.

How to store Trigaine Solution

Store below 30°C in the original pack, away from direct sunlight and moisture. Keep out of the reach of children.

Expert advice for Trigaine Solution

Be consistent — irregular use gives no result. Have persistent or patchy hair loss assessed; thyroid disease, iron deficiency and other causes are treatable. Apply retinoids at night to clean, dry skin, and moisturise afterwards. Give it at least eight to twelve weeks before judging whether it works. Do not pick or squeeze spots — that is what leaves scars.

Manufacturer and class

Manufacturer:

APPLE THERAPEUTICS

Therapeutic class:

Hair and scalp treatment and Anti-acne agent

Drug class:

Hair growth stimulant / anti-dandruff agent and Retinoid / keratolytic