Zyven-OD 50 mg Tablet

Composition of Zyven-OD 50 mg Tablet

Zyven-OD 50 mg Tablet contains Desvenlafaxine extended-release 50 mg. It belongs to the SNRI (Serotonin-norepinephrine reuptake inhibitor) class of medicines.

Uses of Zyven-OD 50 mg Tablet

Treatment of major depressive disorder (depression); may also be used for anxiety symptoms associated with depression as prescribed.

Key benefits

• Helps relieve symptoms of depression
• Improves mood and interest in daily activities
• May reduce anxiety symptoms associated with depression
• Once-daily extended-release dosing

How Zyven-OD 50 mg Tablet works

Desvenlafaxine is a serotonin-norepinephrine reuptake inhibitor (SNRI). It increases levels of serotonin and norepinephrine in the brain, helping improve mood, energy and interest in daily activities.

How to take Zyven-OD 50 mg Tablet

Oral tablet (OD/once daily). Take exactly as prescribed, preferably at the same time each day, with or without food. Swallow whole; do not crush, chew or split extended-release tablets. Do not stop suddenly without medical advice.

Take it exactly as your doctor prescribed. Do not change the dose or stop early on your own.

Missed dose and overdose

If you miss a dose

Take it as soon as you remember. If your next dose is almost due, skip the one you missed — never take two doses together to catch up.

If you take too much

An overdose of this medicine can cause fits, dangerous heart rhythm disturbance and coma, and is particularly dangerous with the older tricyclic medicines. Do not wait for symptoms to appear — go to the nearest emergency department and take the pack or strip with you.

Side effects of Zyven-OD 50 mg Tablet

Most side effects of Zyven-OD are mild and settle as the body adjusts. Reported side effects include:

• nausea
• dizziness
• headache
• dry mouth
• constipation
• sweating
• insomnia
• sleepiness
• decreased appetite
• increased blood pressure
• sexual dysfunction

Stop the medicine and seek help immediately for a rash, swelling of the face or lips, wheezing or difficulty breathing. Tell your doctor about any side effect that persists or worries you.

Safety advice for Zyven-OD 50 mg Tablet

Warnings and precautions

Prescription medicine. Do not use with MAO inhibitors (or within 14 days of stopping an MAOI); wait at least 7 days after stopping desvenlafaxine before starting an MAOI. Monitor for suicidal thoughts/behavior especially in young adults and during dose changes. May increase blood pressure and heart rate—regular BP monitoring advised. Use caution in seizure disorder, bipolar disorder/mania, bleeding disorders, glaucoma (angle-closure risk), hyponatremia risk (elderly/diuretics), and liver/kidney impairment (dose adjustment may be needed). Risk of serotonin syndrome, especially with other serotonergic drugs. Do not stop abruptly—withdrawal symptoms may occur.

Do not take Zyven-OD if

Not for anyone with a known allergy to this medicine or to any ingredient in the pack. Must not be combined with a monoamine oxidase inhibitor, or started within the gap your doctor specifies after one.

Interactions with other medicines

MAO inhibitors (contraindicated), other serotonergic drugs (SSRIs/SNRIs, triptans, tramadol, linezolid, lithium, St John’s wort) increasing serotonin syndrome risk, NSAIDs/aspirin/anticoagulants (increased bleeding risk), alcohol/CNS depressants (additive dizziness/sedation), drugs that raise blood pressure (additive effect), strong CYP3A4 inhibitors may increase levels (clinically modest)

How to store Zyven-OD 50 mg Tablet

Store below 25°C in a dry place, protected from light and moisture. Keep out of reach of children.

Expert advice for Zyven-OD 50 mg Tablet

Give it a fair trial of several weeks, and keep your review appointments. Take it at the same time each day — at night if it makes you drowsy, in the morning if it disturbs sleep. Talking therapy alongside medicine works better than either alone for most people.

Manufacturer and class

Manufacturer:

ZYDUS HEALTHCARE PHARMA

Therapeutic class:

Antidepressant

Drug class:

SNRI (Serotonin-norepinephrine reuptake inhibitor)