Advastat Ez 10MG Tab

Tablet

Management of high cholesterol and mixed dyslipidaemia; reduction of LDL-C and total cholesterol; prevention of cardiovascular events (heart attack, stroke) in at-risk patients as advised by a doctor.

Atorvastatin (a statin) inhibits HMG-CoA reductase, reducing cholesterol synthesis in the liver and increasing LDL clearance. Ezetimibe blocks intestinal absorption of cholesterol by inhibiting NPC1L1, further lowering LDL when combined with a statin.

Tablet for oral use. Take once daily at the same time each day, with or without food, as prescribed. Continue diet/exercise advice; do not stop without medical advice.

Headache, nausea, abdominal pain, diarrhea, constipation, muscle pain (myalgia), fatigue, raised liver enzymes

Prescription-only lipid-lowering medicine. Avoid in active liver disease or unexplained persistent elevation of liver enzymes. Statins can rarely cause muscle injury (myopathy/rhabdomyolysis); seek medical help for unexplained muscle pain/weakness, fever, or dark urine. Use caution in patients with kidney problems, hypothyroidism, heavy alcohol use, or elderly (higher myopathy risk). Periodic lipid profile and liver function monitoring may be advised. Not recommended in pregnancy; avoid breastfeeding.

Strong CYP3A4 inhibitors (e.g., clarithromycin/erythromycin, ketoconazole/itraconazole, protease inhibitors) increase atorvastatin levels; cyclosporine (avoid or close monitoring); fibrates (especially gemfibrozil) and high-dose niacin increase myopathy risk; warfarin (monitor INR); colchicine (myopathy risk); grapefruit juice (avoid/excess use); antacids may reduce atorvastatin absorption slightly; bile acid sequestrants (separate dosing as advised).

Store below 25°C in a cool, dry place. Protect from light and moisture. Keep out of reach of children.

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