Distributor inventory | Drop

Treatment of elevated intraocular pressure in open-angle glaucoma and ocular hypertension

Brimonidine is an alpha-2 adrenergic agonist that reduces aqueous humour production and increases uveoscleral outflow. Timolol is a non-selective beta-blocker that decreases aqueous humour formation, together lowering intraocular pressure.

For ophthalmic use only. Instill 1 drop into the affected eye(s) as prescribed (commonly twice daily, about 12 hours apart). Wash hands, avoid touching dropper tip, remove contact lenses before use and reinsert after at least 15 minutes; use punctal occlusion for 1–2 minutes to reduce systemic absorption.

Eye burning/stinging, eye irritation/redness, blurred vision, dry eyes, foreign body sensation, headache, fatigue/drowsiness, bitter/abnormal taste

Use with caution in patients with asthma/COPD, bradycardia, heart block, heart failure, hypotension (due to timolol). May cause systemic beta-blocker effects; seek help for wheezing, breathing difficulty, slow pulse, fainting. Caution in patients on antihypertensives, cardiac drugs, or with depression (brimonidine). Do not use in active eye infection unless advised. If using other eye drops, keep 5–10 minutes gap. Discard if solution changes color/contains particles.

Other beta-blockers (systemic/ocular), calcium channel blockers, digoxin, antiarrhythmics (risk of bradycardia/AV block), antihypertensives, CNS depressants/alcohol (increased drowsiness), MAO inhibitors and tricyclic antidepressants (may alter brimonidine effects), clonidine (additive effects)

Store below 25°C, protect from light, do not freeze. Keep bottle tightly closed and avoid contamination of dropper tip.

Combigan Eye Drops, Brimodin-T Eye Drops, Brintop-T Eye Drops, Brimolol Eye Drops, Brim-T Eye Drops