Distributor inventory | Tablet

Treatment of hypertension (high blood pressure); chronic stable angina; vasospastic (Prinzmetal’s) angina; to reduce risk of cardiovascular events associated with high blood pressure.

Amlodipine is a dihydropyridine calcium channel blocker. It relaxes blood vessels by reducing calcium entry into vascular smooth muscle, lowering blood pressure and improving blood flow to the heart to relieve angina.

Tablet for oral use. Take as prescribed, usually once daily at the same time each day, with or without food. Swallow with water; do not stop suddenly without medical advice.

Headache,dizziness,flushing,ankle/leg swelling (edema),fatigue,palpitations,nausea,abdominal pain,somnolence

Use with caution in liver impairment (dose adjustment may be needed). May cause dizziness—avoid driving if affected. Monitor for excessive low blood pressure, worsening chest pain at start of therapy, or significant swelling. Use cautiously in severe aortic stenosis, heart failure, and in elderly. Do not discontinue without doctor advice.

Other antihypertensives (additive BP lowering),CYP3A4 inhibitors (e.g., clarithromycin, azole antifungals, ritonavir) may increase amlodipine levels,CYP3A4 inducers (e.g., rifampicin, carbamazepine, phenytoin) may reduce effect,Simvastatin (limit simvastatin dose when co-administered),Grapefruit juice (may increase levels in some patients),Tacrolimus/cyclosporine (levels may change)

Store below 25°C in a dry place. Protect from light and moisture. Keep out of reach of children.

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