Avozosin-T 2.5MG Tab

Tablet

Treatment of autoimmune inflammatory conditions such as rheumatoid arthritis, psoriatic arthritis and ulcerative colitis (as prescribed by specialist); may also be used for other immune-mediated diseases per doctor’s advice

Tofacitinib is a Janus kinase (JAK) inhibitor. It blocks JAK1/JAK3 signaling pathways involved in cytokine activity, thereby reducing immune overactivity, inflammation, pain and tissue damage.

Tablet for oral use. Take exactly as prescribed, at the same time each day, with or without food. Do not stop abruptly without medical advice; if you miss a dose, take it when remembered unless it is close to the next dose.

Upper respiratory tract infection, headache, diarrhea, nausea, abdominal pain, raised liver enzymes, increased cholesterol, rash, herpes zoster (shingles)

Prescription-only immunosuppressant. Increases risk of serious infections (TB, fungal, bacterial, viral); screening for TB/hepatitis may be required before and during therapy. Risk of herpes zoster, blood clots (DVT/PE), major cardiovascular events and certain malignancies may be increased in some patients; seek urgent care for chest pain, breathlessness, unilateral leg swelling, severe abdominal pain. Monitor CBC, liver function and lipids as advised; may cause low blood counts. Avoid live vaccines during treatment; keep vaccinations up to date prior to starting. Use caution in liver/kidney impairment; dose adjustments may be needed.

Strong CYP3A4 inhibitors (ketoconazole, clarithromycin), strong CYP3A4 inducers (rifampicin, carbamazepine, phenytoin), other immunosuppressants/biologics (azathioprine, cyclosporine, tacrolimus, TNF inhibitors), live vaccines

Store below 25°C in a cool, dry place away from light and moisture. Keep in original blister and out of reach of children.

Xeljanz 5 Tablet, Xeljanz XR 11 mg Tablet, Jaknat 5 Tablet, Tofajak 5 Tablet, Tofacitinib 5 mg Tablet (generic)