Neosporin Skin Ointment

Neosporin Skin Ointment contains Bacitracin zinc 250 IU/g + Neomycin sulfate 3.5 mg/g + Polymyxin B sulfate 5000 IU/g. Prescription required.

Prevention and treatment of minor skin infections in small cuts, wounds, abrasions, burns; helps prevent bacterial infection in minor skin injuries

This is a topical triple-antibiotic combination. Bacitracin inhibits bacterial cell wall synthesis, while neomycin (an aminoglycoside) and polymyxin B disrupt bacterial protein synthesis and cell membrane integrity, providing broad antibacterial coverage against common skin pathogens.

For external use only. Clean and dry the affected area, then apply a thin layer 1–3 times daily or as directed by a doctor; may be covered with a sterile bandage. Avoid contact with eyes, mouth and inside the nose; wash hands before and after use.

Mild burning/stinging, itching, redness, rash, dryness, contact dermatitis, allergic reaction

Do not use on large areas, deep puncture wounds, serious burns, or for prolonged periods unless advised by a doctor. Stop use and seek medical advice if irritation, rash, swelling or no improvement in 3–5 days occurs. Avoid use if allergic to bacitracin, neomycin, polymyxin B or other aminoglycosides. Use caution in patients with significant skin barrier damage as neomycin can rarely be absorbed and cause toxicity; avoid in ear if eardrum is perforated.

Other topical antibiotics/antiseptics on same area (increased irritation/sensitization), concurrent aminoglycosides (e.g., gentamicin, amikacin) if significant systemic absorption occurs, neuromuscular blockers (theoretical with systemic absorption)

Store below 25°C in a cool, dry place. Keep tube tightly closed and protect from excessive heat and moisture.

Generic triple antibiotic ointment (Bacitracin + Neomycin + Polymyxin B), Bactoderm Ointment, Polybact Ointment, Nebasulf Ointment, Soframycin Cream (framycetin)