Sitaearth M 500 Tab

Tablet

Type 2 diabetes mellitus: to improve blood sugar control in adults, along with diet and exercise

Sitagliptin is a DPP-4 inhibitor that increases incretin levels, which boosts insulin release and reduces glucagon after meals. Metformin decreases glucose production in the liver and improves insulin sensitivity, helping lower fasting and post-meal blood sugar.

Oral tablet. Usually taken with meals to reduce stomach upset; swallow whole with water. Dose and frequency are as prescribed by the doctor; do not crush or chew. Monitor blood glucose regularly.

Nausea, vomiting, diarrhoea, abdominal pain, loss of appetite, metallic taste, headache, dizziness, nasopharyngitis, upper respiratory tract infection

Prescription medicine. Risk of lactic acidosis with metformin (higher risk in kidney impairment, dehydration, severe infection, shock, heavy alcohol use). Do not use in severe renal impairment; kidney function should be checked before and during treatment. Temporarily stop metformin before/after iodinated contrast procedures and major surgery as advised. Use with caution in liver disease, heart failure, elderly, and in conditions causing low oxygen. Seek help for symptoms of pancreatitis (severe abdominal pain), allergic reactions, or persistent severe GI symptoms. Monitor for hypoglycaemia when used with insulin or sulfonylureas.

Alcohol (increases lactic acidosis risk), insulin and sulfonylureas (increased hypoglycaemia), iodinated contrast media (risk of kidney injury/lactic acidosis; temporary discontinuation), carbonic anhydrase inhibitors like topiramate/acetazolamide (increased metabolic acidosis risk), cationic drugs affecting renal tubular secretion (e.g., cimetidine) may increase metformin levels, ACE inhibitors/ARBs and diuretics (may affect glucose control/renal function)

Store below 25°C in a cool, dry place. Protect from moisture and direct light. Keep out of reach of children.

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