Ursobile-450 mg Tablet

Ursobile-450 mg Tablet contains Ursodeoxycholic Acid (150mg). Prescription required.

Dissolution of cholesterol gallstones (in selected patients), primary biliary cholangitis (primary biliary cirrhosis), cholestatic liver diseases with impaired bile flow

Ursodeoxycholic acid is a hydrophilic bile acid that reduces cholesterol saturation in bile by decreasing hepatic cholesterol secretion and improving bile composition. It also promotes bile flow and has cytoprotective effects on bile duct and liver cells, helping improve cholestasis and liver enzyme abnormalities.

Tablet for oral use. Take exactly as prescribed, preferably with food or after meals to improve absorption and reduce stomach upset. Swallow whole with water; do not crush/chew unless advised. Dose and duration depend on indication (e.g., gallstones/PBC) and body weight.

Diarrhoea, nausea, abdominal pain, indigestion, constipation, headache, dizziness, rash/itching, transient increase in liver enzymes

Use with caution in patients with severe liver disease, acute inflammation of gallbladder/bile ducts, or obstruction of the biliary tract. Not suitable for calcified or pigment gallstones and for non-functioning gallbladder. Monitor liver function tests periodically; ultrasound/assessment may be needed for gallstones. Seek medical help for severe abdominal pain, persistent diarrhoea, jaundice worsening, or allergic reactions.

Bile acid sequestrants (cholestyramine, colestipol) and antacids containing aluminium (e.g., aluminium hydroxide/smectite) reduce absorption; separate dosing by 2-4 hours. Oestrogens/oral contraceptives and lipid-lowering drugs like clofibrate may increase cholesterol in bile and reduce gallstone dissolution. May affect blood levels of ciclosporin; monitor if used together.

Store below 25°C in a dry place, protected from light and moisture. Keep in original blister pack and out of reach of children.

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