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Maintenance treatment of asthma and chronic obstructive pulmonary disease (COPD) where inhaled corticosteroid (ICS) plus long-acting beta2-agonist (LABA) therapy is appropriate; helps prevent wheezing and breathlessness and reduces exacerbations.

Fluticasone furoate is an inhaled corticosteroid that reduces airway inflammation, swelling and mucus production. Vilanterol is a long-acting beta2-agonist that relaxes airway smooth muscles to keep airways open for prolonged relief. Together they improve breathing control and reduce flare-ups when used regularly.

For inhalation use only. Use exactly as prescribed, typically once daily at the same time each day. Rinse mouth with water and spit after each use to reduce risk of oral thrush. Not for immediate relief of sudden breathing attacks—keep a rescue inhaler (e.g., salbutamol) available.

Headache,throat irritation,hoarseness (dysphonia),cough,oral thrush (candidiasis),nasopharyngitis,upper respiratory tract infection,nausea,palpitations,tremor

Do not use for acute bronchospasm/status asthmaticus. LABA-containing medicines must be used with an ICS in asthma; use only as prescribed. Risk of oral candidiasis—rinse mouth after use. Use with caution in patients with cardiovascular disease, arrhythmias, hypertension, hyperthyroidism, diabetes, glaucoma, osteoporosis, liver impairment, and in those with infections (including TB). Long-term/high-dose ICS may cause adrenal suppression, reduced bone mineral density, cataract/glaucoma and growth effects in children. Seek medical help if breathing worsens, rescue inhaler is needed more often, or signs of pneumonia occur (especially in COPD).

Strong CYP3A4 inhibitors (e.g., ketoconazole, itraconazole, ritonavir/cobicistat) may increase fluticasone/vilanterol exposure and systemic steroid/beta-agonist effects; beta-blockers may reduce bronchodilation; other sympathomimetics may increase cardiovascular effects; diuretics/xanthines/systemic steroids may increase risk of hypokalemia; MAO inhibitors or tricyclic antidepressants may potentiate beta-agonist cardiovascular effects; other LABA-containing inhalers should be avoided.

Store below 30°C in a cool, dry place away from direct heat/sunlight. Do not freeze. Keep inhaler in original pack and out of reach of children.

Relvar Ellipta 100/25 inhaler,Airduo Respiclick (fluticasone/salmeterol) inhaler,Seretide/Seroflo (fluticasone propionate/salmeterol) inhaler,Symbicort (budesonide/formoterol) inhaler,Foracort (budesonide/formoterol) inhaler