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Intas Pharmaceuticals Ltd - Tablet - 250mg - 10 S
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Imipramine (25mg)
Delivery across India. Free above ₹999; ₹49 from ₹499, ₹99 below. Chennai express delivery is chargeable.
This medicine needs a prescription.
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Depsol 25 is used for bed-wetting Depression.
Medically reviewed by Dr. Balaji Krishnan, MBBS · Updated September 2026
Depsol 25 contains Imipramine (25mg). It belongs to the Antidepressant class of medicines.
Bed-wetting Depression
Imipramine works by increasing the levels of certain natural chemicals (like serotonin and norepinephrine) in the brain that influence mood and emotions. It restores their balance, helps improve mood, relieves feelings of sadness, and reduces anxiety linked with depression.
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Depsol 25mg Tablet may be taken with or without food.
Take it exactly as your doctor prescribed. Do not change the dose or stop early on your own.
If you miss a dose of Depsol 25mg Tablet, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.\n
An overdose of this medicine can cause fits, dangerous heart rhythm disturbance and coma, and is particularly dangerous with the older tricyclic medicines. Do not wait for symptoms to appear — go to the nearest emergency department and take the pack or strip with you.
Most side effects of Depsol are mild and settle as the body adjusts. Reported side effects include:
Stop the medicine and seek help immediately for a rash, swelling of the face or lips, wheezing or difficulty breathing. Tell your doctor about any side effect that persists or worries you.
| Pregnancy | Pregnancy CONSULT YOUR DOCTOR |
|---|---|
| Breastfeeding | Breast feeding CONSULT YOUR DOCTOR |
| Alcohol | Alcohol UNSAFE |
| Driving | Driving UNSAFE |
| Kidney | Kidney CAUTION |
| Liver | Liver CAUTION |
| Habit forming | No |
These medicines take two to four weeks to begin working, and longer for the full effect. Stopping at two weeks because nothing has changed is the commonest mistake. Never stop suddenly. Abrupt withdrawal causes dizziness, electric-shock sensations, irritability and flu-like symptoms — your doctor will reduce the dose gradually. Tell your doctor or go to hospital immediately if thoughts of harming yourself appear or worsen, particularly in the first weeks or after a dose change, and especially in anyone under twenty-five. Seek urgent care for agitation with fever, shivering, a racing heart, muscle twitching or confusion, particularly if more than one medicine affecting serotonin is being taken. Side effects are usually worst in the first fortnight and then settle.
Not for anyone with a known allergy to this medicine or to any ingredient in the pack. Must not be combined with a monoamine oxidase inhibitor, or started within the gap your doctor specifies after one.
Tramadol, triptans for migraine, linezolid, St John's wort and other antidepressants can together raise serotonin dangerously. Anti-inflammatory painkillers and blood thinners increase the bleeding risk when combined with this group.
Store below 30°C in the original pack, away from direct sunlight and moisture. Keep out of the reach of children.
Depsol 25mg Tablet is used for the treatment of depression and bedwetting in children. The main dose should be taken at night as this medicine may produce drowsiness or sleepiness. You may be asked for regular blood tests to monitor the blood cell count or level of sodium and sugar in the blood. Inform your doctor if you notice behavioral changes, mood changes and suicidal thoughts while taking this medicine. Do not drive or do anything that requires concentration until you know how this medicine affects you. Do not stop taking the medication suddenly without talking to your doctor. The main dose should be taken at night as this medicine may produce drowsiness or sleepiness. It can take 2 to 3 weeks for Depsol 25mg Tablet to start working. You should continue the treatment for at least 6 months after you feel better to stop depression from coming back. If your doctor asks you to stop Depsol 25mg Tablet, you should reduce the dose slowly over 4 weeks. You should not discontinue it abruptly. Avoid driving or operating machinery as it may decrease alertness. Avoid consuming alcohol when taking the Depsol 25mg Tablet, as it may cause excessive drowsiness and calmness. The addiction/dependence potential of Depsol 25mg Tablet is very less. It may be extremely dangerous in overdose.
Medicines with the same active ingredient (Imipramine (25mg)). Ask your doctor or pharmacist before switching brands.
| Medicine | Pack | Price | vs Depsol 25 |
|---|---|---|---|
| Depsonil 25 mg TabletAbbott Healthcare Pvt Ltd | tablet · 10`S | ₹17 | 16% more |
| Antidep 25 mg TabletTorrent Pharmaceuticals Ltd | tablet · 10`S | ₹19 | 27% more |

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The information on Depsol 25 is compiled from the manufacturer's prescribing information and the sources below, and is reviewed by a registered medical practitioner. It does not replace advice from your own doctor.