
Alex L Sus
Glenmark Pharmaceuticals - 100 ml
Prescription required
Xylometazoline hydrochloride 0.1% w/v (1 mg/mL) nasal spray
Otrivin Advance Adult Nasal Spray is used for relief of nasal congestion due to common cold, allergic rhinitis (hay fever), sinusitis; may help open blocked nose and improve breathing.
Medically reviewed by Dr. Balaji Krishnan, MBBS · Updated September 2026
Otrivin Advance Adult Nasal Spray contains Xylometazoline hydrochloride 0.1% w/v (1 mg/mL) nasal spray. It belongs to the Topical alpha-adrenergic agonist (imidazoline derivative) class of medicines.
Xylometazoline is an alpha-adrenergic agonist that constricts blood vessels in the nasal mucosa. This reduces swelling and mucus congestion, improving airflow through the nose.
For adults and adolescents ≥12 years: 1 spray in each nostril up to 2-3 times daily as needed. Use for a maximum of 3 consecutive days unless advised by a doctor. Blow nose before use; keep bottle upright and avoid sharing the spray.
Take it exactly as your doctor prescribed. Do not change the dose or stop early on your own.
Apply it as soon as you remember. If it is nearly time for the next application, skip the missed one — applying extra does not make up for it.
An overdose of this medicine may cause a racing heart, restlessness and a rise in blood pressure if swallowed. Do not wait for symptoms to appear — go to the nearest emergency department and take the pack or strip with you.
Most side effects of Otrivin Advance Adult Nasal are mild and settle as the body adjusts. Reported side effects include:
Stop the medicine and seek help immediately for a rash, swelling of the face or lips, wheezing or difficulty breathing. Tell your doctor about any side effect that persists or worries you.
| Pregnancy | Consult doctor |
|---|---|
| Breastfeeding | Consult your doctor before using this while breastfeeding. |
| Alcohol | No known interaction |
| Driving | Not expected to affect your ability to drive. |
| Kidney | No dose change is usually needed in kidney disease. |
| Liver | No dose change is usually needed in liver disease. |
| Habit forming | No |
Do not use for more than 3 days (risk of rebound congestion/rhinitis medicamentosa). Use with caution in hypertension, heart disease, hyperthyroidism, diabetes, enlarged prostate, glaucoma. Avoid in atrophic rhinitis or after certain nasal surgeries unless prescribed. Seek medical advice if symptoms persist/worsen. Not recommended for children <12 years for this strength. Do not exceed recommended dose.
Not for anyone with a known allergy to this medicine or to any ingredient in the pack. Decongestant sprays are not suitable for very young children without medical advice.
MAO inhibitors (or within 14 days), tricyclic antidepressants, other sympathomimetics/decongestants, certain antihypertensives (may reduce control of blood pressure)
Store below 25°C in a cool, dry place. Protect from light. Keep container tightly closed; keep out of reach of children.
Blow your nose gently before using the spray. Steam inhalation and saline rinses help without any rebound risk.

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The information on Otrivin Advance Adult Nasal Spray is compiled from the manufacturer's prescribing information and the sources below, and is reviewed by a registered medical practitioner. It does not replace advice from your own doctor.