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Pantoprazole (enteric-coated) 40 mg + Domperidone (sustained-release) 30 mg
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Pantoka D Capsule is used for gastroesophageal reflux disease (GERD), heartburn/acid reflux, gastritis and acid-peptic disorders, nausea/vomiting associated with acidity or delayed gastric emptying.
Medically reviewed by Dr. Balaji Krishnan, MBBS · Updated September 2026
Pantoka D Capsule contains Pantoprazole (enteric-coated) 40 mg + Domperidone (sustained-release) 30 mg. It belongs to the Proton pump inhibitor (pantoprazole) + Dopamine D2 antagonist prokinetic/antiemetic (domperidone) class of medicines.
Pantoprazole is a proton pump inhibitor that reduces stomach acid by irreversibly blocking the H+/K+ ATPase pump in gastric parietal cells. Domperidone is a dopamine (D2) receptor antagonist that increases gastric motility and helps relieve nausea/vomiting by enhancing gastric emptying.
Capsule; take as advised by doctor. Commonly taken once daily, 30 minutes before food (preferably before breakfast). Swallow whole; do not crush or chew (due to enteric-coated/ SR components).
Take it exactly as your doctor prescribed. Do not change the dose or stop early on your own.
Take it as soon as you remember. If your next dose is almost due, skip the one you missed — never take two doses together to catch up.
An overdose of this medicine may cause confusion, blurred vision, sweating and a fast heartbeat. It can cause drowsiness, disorientation and abnormal muscle movements. Do not wait for symptoms to appear — go to the nearest emergency department and take the pack or strip with you.
Most side effects of Pantoka D are mild and settle as the body adjusts. Reported side effects include:
Stop the medicine and seek help immediately for a rash, swelling of the face or lips, wheezing or difficulty breathing. Tell your doctor about any side effect that persists or worries you.
| Pregnancy | Consult doctor (domperidone use in pregnancy generally requires medical supervision) |
|---|---|
| Breastfeeding | Consult your doctor before using this while breastfeeding. |
| Alcohol | Use with caution (alcohol can worsen acidity/GERD and may increase dizziness) |
| Driving | May cause drowsiness or affect your concentration. Do not drive until you know how it affects you. |
| Kidney | Use with caution if you have kidney disease — your doctor may adjust the dose or monitor your kidney function. |
| Liver | Consult your doctor if you have liver disease. |
| Habit forming | No |
Use only on medical advice. Domperidone may increase risk of QT prolongation/serious arrhythmias—avoid in known QT prolongation, significant heart disease, or with electrolyte disturbances; seek help for palpitations/fainting. Caution in liver impairment; avoid domperidone in moderate to severe hepatic impairment. Long-term PPI use may be associated with low magnesium, vitamin B12 deficiency, bone fracture risk, and intestinal infections; use lowest effective dose. Consult doctor if alarm symptoms occur (blood in vomit/stool, unexplained weight loss, persistent vomiting, difficulty swallowing).
Not for anyone with a known allergy to this medicine or to any ingredient in the pack. Not for people with bleeding, blockage or perforation of the gut, or with certain heart rhythm disorders.
QT-prolonging drugs (e.g., amiodarone, sotalol, certain antipsychotics), macrolide antibiotics (erythromycin/clarithromycin), azole antifungals (ketoconazole/fluconazole), protease inhibitors, other strong CYP3A4 inhibitors (increase domperidone levels), warfarin (monitor), digoxin, methotrexate (high dose), drugs needing acidic pH for absorption (ketoconazole, itraconazole, iron salts)
Store below 25°C in a dry place, protected from light and moisture. Keep in original blister pack. Keep out of reach of children.
Take it before breakfast, not after a meal. Eat smaller meals, avoid late dinners, raise the head of your bed and avoid smoking — these do as much as the tablet for reflux. Take it shortly before meals for bloating and early fullness. Sip fluids frequently in small amounts, and use oral rehydration salts if you have been vomiting.

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The information on Pantoka D Capsule is compiled from the manufacturer's prescribing information and the sources below, and is reviewed by a registered medical practitioner. It does not replace advice from your own doctor.