Pari CR Plus Tablet

Composition of Pari CR Plus Tablet

Pari CR Plus Tablet contains Paroxetine (12.5mg) + Clonazepam (0.5mg). It belongs to the Antidepressant and Benzodiazepine / sedative-hypnotic class of medicines.

Uses of Pari CR Plus Tablet

Depression

Key benefits

• In Depression Pari CR Plus Tablet works by affecting the balance of certain chemicals (such as serotonin) in the brain. It helps improve mood and feelings of wellbeing
• relieve anxiety and tension
• helps you sleep better
• and increase your energy level. It is an effective antidepressant but may cause drowsiness. You need to take it regularly as it is prescribed for it to be most effective and should not stop taking it suddenly.

How Pari CR Plus Tablet works

Pari CR Plus Tablet is a combination of two medicines, paroxetine and clonazepam, which have mood-enhancing and anxiety-lowering effects. Paroxetine is a selective serotonin reuptake inhibitor (SSRI), which increases the levels of serotonin, a chemical messenger that improves mood. Clonazepam is a benzodiazepine (BZD) that increases the action of GABA, a chemical messenger that suppresses the abnormal activity of the nerve cells in the brain.

How to take Pari CR Plus Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Pari CR Plus Tablet may be taken with or without food.

Take it exactly as your doctor prescribed. Do not change the dose or stop early on your own.

Missed dose and overdose

If you miss a dose

If you miss a dose of Pari CR Plus Tablet, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.

If you take too much

An overdose of this medicine can cause fits, dangerous heart rhythm disturbance and coma, and is particularly dangerous with the older tricyclic medicines. It can cause deep unconsciousness and dangerously slow breathing, particularly with alcohol or an opioid. Do not wait for symptoms to appear — go to the nearest emergency department and take the pack or strip with you.

Side effects of Pari CR Plus Tablet

Most side effects of Pari CR Plus are mild and settle as the body adjusts. Reported side effects include:

• Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Stop the medicine and seek help immediately for a rash, swelling of the face or lips, wheezing or difficulty breathing. Tell your doctor about any side effect that persists or worries you.

Safety advice for Pari CR Plus Tablet

Warnings and precautions

These medicines take two to four weeks to begin working, and longer for the full effect. Stopping at two weeks because nothing has changed is the commonest mistake. Never stop suddenly. Abrupt withdrawal causes dizziness, electric-shock sensations, irritability and flu-like symptoms — your doctor will reduce the dose gradually. Tell your doctor or go to hospital immediately if thoughts of harming yourself appear or worsen, particularly in the first weeks or after a dose change, and especially in anyone under twenty-five. Seek urgent care for agitation with fever, shivering, a racing heart, muscle twitching or confusion, particularly if more than one medicine affecting serotonin is being taken. Side effects are usually worst in the first fortnight and then settle. These medicines cause dependence. They are intended for the shortest possible course — usually two to four weeks — and are not a long-term treatment for anxiety or sleeplessness. Never stop a regular course suddenly. Withdrawal can cause severe anxiety, tremor and fits. Your doctor will taper it slowly. Do not drive or operate machinery. Drowsiness and slowed reactions can continue into the next day. Never combine with alcohol or with opioid painkillers — together they can stop your breathing. Older people are far more likely to fall, become confused or have memory problems on these medicines. Several of these are Schedule H1 medicines and must be dispensed against a prescription and entered in the pharmacy register.

Do not take Pari CR Plus if

Not for anyone with a known allergy to this medicine or to any ingredient in the pack. Must not be combined with a monoamine oxidase inhibitor, or started within the gap your doctor specifies after one. Not for people with severe breathing problems, sleep apnoea, or severe liver disease. Not for anyone with a history of dependence, except under specialist supervision.

Interactions with other medicines

Tramadol, triptans for migraine, linezolid, St John's wort and other antidepressants can together raise serotonin dangerously. Anti-inflammatory painkillers and blood thinners increase the bleeding risk when combined with this group. Alcohol, opioids, antihistamines, muscle relaxants and other sedatives all deepen the sedation, sometimes fatally.

How to store Pari CR Plus Tablet

Store below 30°C in the original pack, away from direct sunlight and moisture. Keep out of the reach of children.

Expert advice for Pari CR Plus Tablet

Take Pari CR Plus Tablet with a snack or just after eating breakfast, as this will help to reduce the likelihood of you feeling sick as a side effect. It can take a week or two after starting this treatment before the effect begins to build up, and 4-6 weeks before you feel the full benefit. Do not stop taking it after a week or two if you feel it is not helping. Avoid taking antacids 2 hours before or after taking Pari CR Plus Tablet, as they make it harder for your body to absorb the medicine. Inform your doctor immediately if you have thoughts about harming yourself or ending your life. If you have diabetes, you will be asked to monitor your blood glucose level regularly, as this medicine may affect the levels of sugar in your blood. Try to keep your regular appointments with your doctor. This is so your doctor can check on your progress.

Manufacturer and class

Manufacturer:

IPCA LABORATORIES LTD`

Therapeutic class:

NEURO CNS

Drug class:

Antidepressant and Benzodiazepine / sedative-hypnotic