
Actibile 150 mg Tablet
Zydus Healthcare Pharma - Tablet - 150 mg - 10 S
Prescription required
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Paroxetine (12.5mg) + Clonazepam (0.5mg)
Available at our pharmacy counter
This medicine is dispensed in person against a valid prescription and is not sold online. Ask our pharmacist about availability, or speak to a registered doctor.
In-store reference price ₹264
Xet CR Plus 12.5 is used for depression.
Xet CR Plus 12.5 contains Paroxetine (12.5mg) + Clonazepam (0.5mg). It belongs to the Antidepressant and Benzodiazepine / sedative-hypnotic class of medicines.
Depression
Xet CR Plus 12.5 Capsule is a combination of two medicines, paroxetine and clonazepam, which have mood-enhancing and anxiety-lowering effects. Paroxetine is a selective serotonin reuptake inhibitor (SSRI), which increases the levels of serotonin, a chemical messenger that improves mood. Clonazepam is a benzodiazepine (BZD) that increases the action of GABA, a chemical messenger that suppresses the abnormal activity of the nerve cells in the brain.
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Xet CR Plus 12.5 Capsule may be taken with or without food.
Take it exactly as your doctor prescribed. Do not change the dose or stop early on your own.
If you miss a dose of Xet CR Plus 12.5 Capsule, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
An overdose of this medicine can cause fits, dangerous heart rhythm disturbance and coma, and is particularly dangerous with the older tricyclic medicines. It can cause deep unconsciousness and dangerously slow breathing, particularly with alcohol or an opioid. Do not wait for symptoms to appear — go to the nearest emergency department and take the pack or strip with you.
Most side effects of Xet CR Plus are mild and settle as the body gets used to the medicine. The ones reported most often are:
Stop the medicine and get help at once for a rash, swelling of the face or lips, wheezing or difficulty breathing. Tell your doctor about any side effect that persists or worries you.
These medicines take two to four weeks to begin working, and longer for the full effect. Stopping at two weeks because nothing has changed is the commonest mistake. Never stop suddenly. Abrupt withdrawal causes dizziness, electric-shock sensations, irritability and flu-like symptoms — your doctor will reduce the dose gradually. Tell your doctor or go to hospital immediately if thoughts of harming yourself appear or worsen, particularly in the first weeks or after a dose change, and especially in anyone under twenty-five. Seek urgent care for agitation with fever, shivering, a racing heart, muscle twitching or confusion, particularly if more than one medicine affecting serotonin is being taken. Side effects are usually worst in the first fortnight and then settle. These medicines cause dependence. They are intended for the shortest possible course — usually two to four weeks — and are not a long-term treatment for anxiety or sleeplessness. Never stop a regular course suddenly. Withdrawal can cause severe anxiety, tremor and fits. Your doctor will taper it slowly. Do not drive or operate machinery. Drowsiness and slowed reactions can continue into the next day. Never combine with alcohol or with opioid painkillers — together they can stop your breathing. Older people are far more likely to fall, become confused or have memory problems on these medicines. Several of these are Schedule H1 medicines and must be dispensed against a prescription and entered in the pharmacy register.
Not for anyone with a known allergy to this medicine or to any ingredient in the pack. Must not be combined with a monoamine oxidase inhibitor, or started within the gap your doctor specifies after one. Not for people with severe breathing problems, sleep apnoea, or severe liver disease. Not for anyone with a history of dependence, except under specialist supervision.
Tramadol, triptans for migraine, linezolid, St John's wort and other antidepressants can together raise serotonin dangerously. Anti-inflammatory painkillers and blood thinners increase the bleeding risk when combined with this group. Alcohol, opioids, antihistamines, muscle relaxants and other sedatives all deepen the sedation, sometimes fatally.
Store below 30°C in the original pack, away from direct sunlight and moisture. Keep out of the reach of children.
Medicines with the same active ingredient (Paroxetine (12.5mg) + Clonazepam (0.5mg)). Ask your doctor or pharmacist before switching brands.
| Medicine | Pack | Price | vs Xet CR Plus 12.5 |
|---|---|---|---|
| Clonotril P 12.5 mg TabletTorrent Pharmaceuticals Ltd | tablet · 15`S | ₹252 | 4% cheaper |

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Compiled from the manufacturer's prescribing information and the sources below, and reviewed by a registered pharmacist. It does not replace your own doctor's advice.