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Prescription requiredZydus Healthcare PharmaNEURO CNS

Xet CR Plus 12.5

Paroxetine (12.5mg) + Clonazepam (0.5mg)

Available at our pharmacy counter

This medicine is dispensed in person against a valid prescription and is not sold online. Ask our pharmacist about availability, or speak to a registered doctor.

In-store reference price ₹264

Xet CR Plus 12.5 is used for depression.

Licensed pharmacyPharmacist-verified order

Key details

Salt: Paroxetine (12.5mg) + Clonazepam (0.5mg)
Available variants: NA 10`S
Price: ₹264
Prescription: Required
Manufacturer: ZYDUS HEALTHCARE PHARMA

Ordering notes

This medicine is dispensed in person at a licensed pharmacy counter and is not delivered.
Returns & refunds: orders can be cancelled before dispatch; after dispatch, returns depend on the item category. Read the full policy

Composition of Xet CR Plus 12.5

Xet CR Plus 12.5 contains Paroxetine (12.5mg) + Clonazepam (0.5mg). It belongs to the Antidepressant and Benzodiazepine / sedative-hypnotic class of medicines.

Uses of Xet CR Plus 12.5

Depression

Benefits of Xet CR Plus 12.5

In Depression
Xet CR Plus restores the balance of the brain's chemical messengers, gradually lifting mood, energy, sleep and appetite. The benefit builds over several weeks, which is why it is important to keep taking it.
In Anxiety
Xet CR Plus calms persistent worry and the physical tension that goes with it, so that everyday situations feel manageable again.
In Obsessive compulsive disorder
Xet CR Plus reduces the intrusive thoughts and the urge to repeat rituals, usually alongside talking therapy.
In Nerve pain
Xet CR Plus dampens the pain signals from damaged nerves, easing burning, shooting or tingling pain that ordinary painkillers do not touch.
In Migraine prevention
Xet CR Plus, taken every day, reduces how often migraines come and how severe they are. It does not treat an attack once it has started.
In Insomnia
Xet CR Plus helps you fall asleep and stay asleep when sleep has broken down, so you can function the next day while the cause is dealt with.
In Panic disorder
Xet CR Plus reduces the frequency and intensity of panic attacks, giving breathing space for longer-term treatment to work.
In Seizures
Xet CR Plus stops a prolonged seizure or a cluster of seizures quickly, and is used in some forms of epilepsy to prevent them.
In Muscle spasm
Xet CR Plus relaxes severe muscle spasm and the pain it causes, including spasm caused by nerve conditions.

How Xet CR Plus 12.5 works

Xet CR Plus 12.5 Capsule is a combination of two medicines, paroxetine and clonazepam, which have mood-enhancing and anxiety-lowering effects. Paroxetine is a selective serotonin reuptake inhibitor (SSRI), which increases the levels of serotonin, a chemical messenger that improves mood. Clonazepam is a benzodiazepine (BZD) that increases the action of GABA, a chemical messenger that suppresses the abnormal activity of the nerve cells in the brain.

How to take Xet CR Plus 12.5

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Xet CR Plus 12.5 Capsule may be taken with or without food.

Take it exactly as your doctor prescribed. Do not change the dose or stop early on your own.

Missed dose and overdose

If you miss a dose

If you miss a dose of Xet CR Plus 12.5 Capsule, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.

If you take too much

An overdose of this medicine can cause fits, dangerous heart rhythm disturbance and coma, and is particularly dangerous with the older tricyclic medicines. It can cause deep unconsciousness and dangerously slow breathing, particularly with alcohol or an opioid. Do not wait for symptoms to appear — go to the nearest emergency department and take the pack or strip with you.

Side effects of Xet CR Plus 12.5

Most side effects of Xet CR Plus are mild and settle as the body gets used to the medicine. The ones reported most often are:

  • Nausea
  • Dry mouth
  • Drowsiness or difficulty sleeping
  • Headache
  • Weight change
  • Reduced sexual desire
  • Constipation
  • Drowsiness
  • Dizziness
  • Unsteadiness
  • Poor concentration
  • Memory lapses

Stop the medicine and get help at once for a rash, swelling of the face or lips, wheezing or difficulty breathing. Tell your doctor about any side effect that persists or worries you.

Safety advice for Xet CR Plus 12.5

AlcoholUNSAFE
Do not drink alcohol while taking this medicine.
PregnancyUNSAFE
Not recommended in pregnancy. It may harm the developing baby, so tell your doctor at once if you are or might be pregnant.
Breast feedingUNSAFE
Not recommended while breastfeeding.
DrivingUNSAFE
Do not drive or operate machinery while taking this medicine.
KidneyCAUTION
Use with caution if you have kidney disease. Your doctor may adjust the dose or monitor your kidney function.
LiverUNSAFE
Not recommended if you have significant liver disease.
Habit formingYES
This medicine can cause dependence with prolonged use. Take it only under medical supervision and do not stop it abruptly.

Warnings and precautions

These medicines take two to four weeks to begin working, and longer for the full effect. Stopping at two weeks because nothing has changed is the commonest mistake. Never stop suddenly. Abrupt withdrawal causes dizziness, electric-shock sensations, irritability and flu-like symptoms — your doctor will reduce the dose gradually. Tell your doctor or go to hospital immediately if thoughts of harming yourself appear or worsen, particularly in the first weeks or after a dose change, and especially in anyone under twenty-five. Seek urgent care for agitation with fever, shivering, a racing heart, muscle twitching or confusion, particularly if more than one medicine affecting serotonin is being taken. Side effects are usually worst in the first fortnight and then settle. These medicines cause dependence. They are intended for the shortest possible course — usually two to four weeks — and are not a long-term treatment for anxiety or sleeplessness. Never stop a regular course suddenly. Withdrawal can cause severe anxiety, tremor and fits. Your doctor will taper it slowly. Do not drive or operate machinery. Drowsiness and slowed reactions can continue into the next day. Never combine with alcohol or with opioid painkillers — together they can stop your breathing. Older people are far more likely to fall, become confused or have memory problems on these medicines. Several of these are Schedule H1 medicines and must be dispensed against a prescription and entered in the pharmacy register.

Do not take Xet CR Plus if

Not for anyone with a known allergy to this medicine or to any ingredient in the pack. Must not be combined with a monoamine oxidase inhibitor, or started within the gap your doctor specifies after one. Not for people with severe breathing problems, sleep apnoea, or severe liver disease. Not for anyone with a history of dependence, except under specialist supervision.

Interactions with other medicines

Tramadol, triptans for migraine, linezolid, St John's wort and other antidepressants can together raise serotonin dangerously. Anti-inflammatory painkillers and blood thinners increase the bleeding risk when combined with this group. Alcohol, opioids, antihistamines, muscle relaxants and other sedatives all deepen the sedation, sometimes fatally.

How to store Xet CR Plus 12.5

Store below 30°C in the original pack, away from direct sunlight and moisture. Keep out of the reach of children.

Quick tips for Xet CR Plus 12.5

  • Take Xet CR Plus 12.5 Capsule with a snack or just after eating breakfast, as this will help to reduce the likelihood of you feeling sick as a side effect.
  • It can take a week or two after starting this treatment before the effect begins to build up, and 4-6 weeks before you feel the full benefit.
  • Do not stop taking it after a week or two if you feel it is not helping.
  • Avoid taking antacids 2 hours before or after taking Xet CR Plus 12.5 Capsule, as they make it harder for your body to absorb the medicine.
  • Inform your doctor immediately if you have thoughts about harming yourself or ending your life.
  • If you have diabetes, you will be asked to monitor your blood glucose level regularly, as this medicine may affect the levels of sugar in your blood.
  • Try to keep your regular appointments with your doctor.
  • This is so your doctor can check on your progress.

Manufacturer and class

Manufacturer:
ZYDUS HEALTHCARE PHARMA
Therapeutic class:
NEURO CNS
Drug class:
Antidepressant and Benzodiazepine / sedative-hypnotic

Substitutes for Xet CR Plus 12.5

Medicines with the same active ingredient (Paroxetine (12.5mg) + Clonazepam (0.5mg)). Ask your doctor or pharmacist before switching brands.

MedicinePackPricevs Xet CR Plus 12.5
Clonotril P 12.5 mg TabletTorrent Pharmaceuticals Ltdtablet · 15`S₹2524% cheaper
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Xet CR Plus 12.5 FAQs

What is Xet CR Plus 12.5 used for?
Xet CR Plus 12.5 is commonly used for Depression. Always follow your doctor's advice, this information is for educational purposes and not a substitute for professional medical guidance.
What are the benefits of Xet CR Plus 12.5?
Depression: Xet CR Plus restores the balance of the brain's chemical messengers, gradually lifting mood, energy, sleep and appetite. The benefit builds over several weeks, which is why it is important to keep taking it. It is also used for anxiety, obsessive compulsive disorder, nerve pain.
What is the salt in Xet CR Plus 12.5?
Xet CR Plus 12.5 contains Paroxetine (12.5mg) + Clonazepam (0.5mg). If you are allergic to any of these active ingredients or excipients, do not take this medicine and speak to your doctor first.
How should I take Xet CR Plus 12.5?
Take this medicine in the dose and duration as advised by your doctor. Take it exactly as prescribed; do not change the dose or stop early without talking to your doctor.
How does Xet CR Plus 12.5 work?
Xet CR Plus 12.5 Capsule is a combination of two medicines, paroxetine and clonazepam, which have mood-enhancing and anxiety-lowering effects.
Is Xet CR Plus 12.5 a prescription medicine?
Yes. Xet CR Plus 12.5 is a prescription-only (Rx) medicine. Upload a valid prescription from a registered medical practitioner during checkout. We cannot dispense it without a valid Rx.
What are the common side effects of Xet CR Plus 12.5?
The side effects reported most often with Xet CR Plus are Nausea, Dry mouth, Drowsiness or difficulty sleeping, Headache, Weight change. Most are mild and settle as the body adjusts; tell your doctor if any of them persist or worry you, and stop the medicine and seek help at once for a rash, swelling of the face or lips, or difficulty breathing.
Can Xet CR Plus 12.5 be taken during pregnancy?
Xet CR Plus 12.5 is not recommended in pregnancy. Always tell your doctor if you are pregnant, planning a pregnancy or breastfeeding before starting Xet CR Plus.
Can I drink alcohol while taking Xet CR Plus 12.5?
No. Do not drink alcohol while taking Xet CR Plus 12.5.
What if I miss a dose of Xet CR Plus 12.5?
If you miss a dose of Xet CR Plus 12.5 Capsule, take it as soon as possible.
Is Xet CR Plus 12.5 habit forming?
Yes. Xet CR Plus 12.5 can cause dependence with prolonged use. Take Xet CR Plus only as directed and for the duration your doctor advises.
Is there a cheaper substitute for Xet CR Plus 12.5?
Clonotril P 12.5 mg Tablet has the same active ingredient and strength and is listed from ₹252 on PingMeDoc Pharmacy. Ask your doctor or pharmacist before switching brands, the salt is the same, but excipients and release profiles can differ.
How much does Xet CR Plus 12.5 cost on PingMeDoc Pharmacy?
Xet CR Plus 12.5 starts at ₹264 on PingMeDoc Pharmacy. Available in NA 10`S. Final price is confirmed at checkout and may vary by variant and location.
Who manufactures Xet CR Plus 12.5?
Xet CR Plus 12.5 is manufactured by ZYDUS HEALTHCARE PHARMA. PingMeDoc Pharmacy sources medicines only from licensed manufacturers and distributors.
How is Xet CR Plus 12.5 delivered?
Xet CR Plus 12.5 is a regulated medicine and is not delivered. It is dispensed in person at a licensed pharmacy counter against a valid prescription. Ask our pharmacist on WhatsApp about availability.

Xet CR Plus 12.5, Quick facts

Salt
Paroxetine (12.5mg) + Clonazepam (0.5mg)
Price
₹264
Prescription
Required (Rx)
Schedule
Schedule H
Brand
ZYDUS HEALTHCARE PHARMA
Manufacturer
ZYDUS HEALTHCARE PHARMA
Therapeutic class
NEURO CNS
Drug class
Antidepressant and Benzodiazepine / sedative-hypnotic
Habit forming
Yes
Variants
NA 10`S
Delivery
Standard across India

References

Compiled from the manufacturer's prescribing information and the sources below, and reviewed by a registered pharmacist. It does not replace your own doctor's advice.

  1. PingMeDoc clinical monograph library — compiled from Indian package inserts, the Indian Pharmacopoeia
  2. CDSCO schedules and standard pharmacology references. Reviewed for patient readability. This is general information, not a substitute for your doctor's advice.
  3. Central Drugs Standard Control Organisation (CDSCO), Ministry of Health & Family Welfare, Government of India, approved drug and schedule listings.
  4. National List of Essential Medicines (NLEM) 2022, Government of India.
  5. Manufacturer's package insert / prescribing information for Xet CR Plus 12.5.
  6. World Health Organization, ATC/DDD classification and Model Formulary for the active ingredient.

Next steps

Safety disclaimer

Product information is for general awareness and does not replace professional medical advice. Always follow a clinician's guidance and upload a valid prescription when required.