Pregain Nt Tablet

Composition of Pregain Nt Tablet

Pregain Nt Tablet contains Pregabalin + Nortriptyline (strengths vary by brand; commonly Pregabalin 75 mg + Nortriptyline 10 mg). It belongs to the Gabapentinoid (pregabalin) + Tricyclic antidepressant (nortriptyline) class of medicines.

Uses of Pregain Nt Tablet

• Neuropathic (nerve) pain such as diabetic neuropathy
• post-herpetic neuralgia
• sciatica/radiculopathy
• neuropathic pain associated with spinal disorders; also used when nerve pain has burning
• tingling or shooting character.

Key benefits

• Reduces burning/tingling nerve pain
• Improves sleep disturbed by neuropathic pain
• Provides dual-mechanism pain relief
• Helps chronic radicular/sciatic pain symptoms

How Pregain Nt Tablet works

Pregabalin reduces abnormal nerve signaling by binding to the alpha-2-delta subunit of voltage-gated calcium channels, decreasing release of pain neurotransmitters. Nortriptyline is a tricyclic antidepressant that increases norepinephrine/serotonin in pain pathways and modulates nerve pain. Together they provide enhanced relief in chronic neuropathic pain.

How to take Pregain Nt Tablet

Tablet; take exactly as prescribed, usually once daily at night (may cause drowsiness). Can be taken with or without food; swallow whole with water. Do not stop suddenly—dose should be tapered by a doctor.

Take it exactly as your doctor prescribed. Do not change the dose or stop early on your own.

Missed dose and overdose

If you miss a dose

Take the missed dose of Pregain Nt as soon as you remember. If it is almost time for the next dose, skip the missed one and carry on with the usual schedule. Do not take two doses together to make up for a missed dose.

If you take too much

Taking more Pregain Nt than prescribed can be harmful. If you suspect an overdose, contact a doctor or go to the nearest emergency department at once, and carry the pack or strip with you. In India the emergency number is 112.

Side effects of Pregain Nt Tablet

Most side effects of Pregain Nt are mild and settle as the body adjusts. Reported side effects include:

• Dizziness
• drowsiness/somnolence
• dry mouth
• constipation
• blurred vision
• weight gain
• peripheral edema (swelling)
• difficulty concentrating
• fatigue

Stop the medicine and seek help immediately for a rash, swelling of the face or lips, wheezing or difficulty breathing. Tell your doctor about any side effect that persists or worries you.

Safety advice for Pregain Nt Tablet

Warnings and precautions

May cause sleepiness, dizziness and blurred vision—avoid driving/operating machinery until effects are known. Use caution in elderly, patients with kidney disease (pregabalin dose adjustment), glaucoma, urinary retention, heart disease/arrhythmias, constipation, and in those with history of substance misuse. Risk of suicidal thoughts/behavior with antiepileptics; seek help for mood changes. Nortriptyline can cause anticholinergic effects and may affect heart rhythm; overdose can be serious. Do not stop abruptly to avoid withdrawal symptoms.

Interactions with other medicines

Alcohol and other CNS depressants (opioids, benzodiazepines, antihistamines) increase sedation/respiratory depression; MAO inhibitors (contraindicated/avoid); other antidepressants/serotonergic drugs (risk of serotonin syndrome); anticholinergics (additive dry mouth/constipation/urinary retention); QT-prolonging drugs/antiarrhythmics (arrhythmia risk); tramadol (seizure/serotonin risk); gabapentin (additive dizziness/sedation).

How to store Pregain Nt Tablet

Store below 25°C in a cool, dry place; protect from moisture and light; keep out of reach of children.

Manufacturer and class

Manufacturer:

LA LIFE SCIENCES

Therapeutic class:

Neuropathic pain (analgesic)

Drug class:

Gabapentinoid (pregabalin) + Tricyclic antidepressant (nortriptyline)