
Amrfy Cream
H & H Pharmaceutical Pvt Ltd - Cream - 0.25%W/W - 30 G
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Prescription required
Salicylic Acid (6%w/v) + Clobetasol (0.05%w/v)
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Propysalic Plus 6% Lotion is used for topisal 6% Lotion is used in the treatment of eczema and psoriasis.
Medically reviewed by Dr. Balaji Krishnan, MBBS · Updated September 2026
Propysalic Plus 6% Lotion contains Salicylic Acid (6%w/v) + Clobetasol (0.05%w/v). It belongs to the Retinoid / keratolytic and Corticosteroid / calcineurin inhibitor class of medicines.
Topisal 6% Lotion is used in the treatment of eczema and psoriasis.
Topisal 6% Lotion is a combination of two medicines: Clobetasol and Salicylic Acid, which treats eczema and psoriasis. Clobetasol is a steroid which blocks the production of certain chemical messengers (prostaglandins) that make the skin red, swollen and itchy. Salicylic Acid is a keratolytic medicine which breaks down keratin clumps, removes dead skin cells and softens the skin. It also enhances the absorption of Clobetasol into the skin.
Clean and dry the affected area, then apply a thin layer and rub it in gently. Wash your hands before and after use, unless your hands are the area being treated. This is for use on the skin only — do not swallow it. Follow the dose and the duration written on your prescription.
Take it exactly as your doctor prescribed. Do not change the dose or stop early on your own.
Apply it as soon as you remember. If it is nearly time for the next application, skip the missed one — applying extra does not make up for it.
An overdose of this medicine can cause severe irritation when far too much cream is applied; an oral retinoid taken in excess can cause headache, vomiting and liver injury. It can suppress the body's own steroid production when it is used for a long time over large areas, especially in children. Do not wait for symptoms to appear — go to the nearest emergency department and take the pack or strip with you.
Most side effects of Propysalic Plus 6% are mild and settle as the body adjusts. Reported side effects include:
Stop the medicine and seek help immediately for a rash, swelling of the face or lips, wheezing or difficulty breathing. Tell your doctor about any side effect that persists or worries you.
| Pregnancy | Topisal 6% Lotion may be unsafe to use during pregnancy.<br>Animal studies have shown adverse effects on the foetus, however, there are limited human studies. The benefits from use in pregnant women may be acceptable despite the risk. Please consult your doctor. |
|---|---|
| Breastfeeding | Topisal 6% Lotion is probably safe to use during lactation. Limited human data suggests that the drug does not represent a significant risk to the baby. |
| Alcohol | Alcohol may worsen the side effects of this medicine. Limit it. |
| Driving | Not expected to affect your ability to drive. |
| Kidney | Use with caution if you have kidney disease — your doctor may adjust the dose or monitor your kidney function. |
| Liver | Consult your doctor if you have liver disease. |
| Habit forming | No |
Acne often looks worse for the first two to four weeks before it improves. This is expected — do not stop. Use sunscreen every day. These medicines make the skin burn much more easily. Oral isotretinoin must never be taken in pregnancy — it causes severe birth defects. Reliable contraception and the pregnancy tests your dermatologist requires are essential before, during and after the course. Start with alternate nights and build up, and do not use more than a pea-sized amount for the whole face. Do not combine several strong acne actives at once without advice — the irritation compounds. Use it only on the area and for the number of days your doctor specified. Potent steroid creams thin the skin permanently when used for too long. Never use a potent steroid cream on the face, the groin or the underarms unless your doctor has specifically told you to — the skin there is thin and absorbs much more. Do not use it on an infection. A steroid on ringworm, impetigo or herpes makes the infection worse while hiding it. Do not use leftover cream on a new rash, and never pass it to someone else. Stop and see your doctor if the area becomes more painful, weepy or crusted.
Not for anyone with a known allergy to this medicine or to any ingredient in the pack. Oral retinoids are absolutely contraindicated in pregnancy and in anyone who might become pregnant without a pregnancy prevention programme. Topical retinoids are avoided in pregnancy. Not for untreated bacterial, fungal or viral skin infections. Not for use in or around the eyes.
Do not combine with other peeling agents or with waxing and harsh scrubs. Oral retinoids must not be combined with tetracycline antibiotics. No significant interactions are expected from preparations used on the skin.
Store below 30°C, away from direct sunlight. Close the cap tightly after each use. Keep out of the reach of children.
Apply retinoids at night to clean, dry skin, and moisturise afterwards. Give it at least eight to twelve weeks before judging whether it works. Do not pick or squeeze spots — that is what leaves scars. Apply a thin layer — a fingertip's worth covers an area about the size of two adult palms. Use a plain moisturiser generously alongside it; that is what keeps eczema away between flares. Ask your doctor for a written plan of how long to use it and when to step down.

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The information on Propysalic Plus 6% Lotion is compiled from the manufacturer's prescribing information and the sources below, and is reviewed by a registered medical practitioner. It does not replace advice from your own doctor.