Terfine 250

Composition of Terfine 250

Terfine 250 contains Terbinafine (250mg). It belongs to the Allylamine antifungal (squalene epoxidase inhibitor) class of medicines.

Uses of Terfine 250

• Treatment of fungal infections such as onychomycosis (fungal nail infection)
• tinea corporis (ringworm)
• tinea cruris (jock itch) and tinea pedis (athlete’s foot) when systemic therapy is required.

Key benefits

• Treats fungal nail infections
• Clears ringworm and other dermatophyte skin infections
• Reduces itching and scaling
• Fungicidal action against dermatophytes

How Terfine 250 works

Terbinafine is an antifungal (allylamine) that inhibits the enzyme squalene epoxidase in fungi. This blocks ergosterol synthesis and leads to buildup of toxic squalene, causing fungal cell death.

How to take Terfine 250

Take orally as prescribed by the doctor, usually once daily. Can be taken with or without food; take at the same time each day and swallow with water. Duration depends on site of infection (skin typically weeks; nail infections often several weeks to months); do not stop early without medical advice.

Take it exactly as your doctor prescribed. Do not change the dose or stop early on your own.

Missed dose and overdose

If you miss a dose

If you miss a dose of Terfine 250mg Tablet, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.

If you take too much

An overdose of this medicine can cause vomiting, liver injury and heart rhythm disturbance. Do not wait for symptoms to appear — go to the nearest emergency department and take the pack or strip with you.

Side effects of Terfine 250

Most side effects of Terfine are mild and settle as the body adjusts. Reported side effects include:

• Nausea
• abdominal pain
• diarrhoea
• dyspepsia
• headache
• rash
• itching
• taste disturbance
• loss of appetite
• fatigue
• elevated liver enzymes

Stop the medicine and seek help immediately for a rash, swelling of the face or lips, wheezing or difficulty breathing. Tell your doctor about any side effect that persists or worries you.

Safety advice for Terfine 250

Warnings and precautions

Prescription medicine. Rare but serious liver injury has been reported—avoid in active/chronic liver disease; baseline and periodic liver function tests may be advised. Stop and seek medical help if symptoms of liver problems occur (persistent nausea, vomiting, abdominal pain, dark urine, jaundice, unusual tiredness). Rare severe skin reactions and blood disorders can occur. Use caution in kidney impairment, psoriasis, or lupus. If dizziness occurs, avoid driving/operating machinery.

Do not take Terfine if

Not for anyone with a known allergy to this medicine or to any ingredient in the pack. Not for people with active liver disease, and several are not for use in pregnancy. Itraconazole is not for people with heart failure.

Interactions with other medicines

Rifampicin (may reduce terbinafine levels), cimetidine (may increase levels), antidepressants metabolized by CYP2D6 (e.g., TCAs, SSRIs such as fluoxetine/paroxetine), beta-blockers (e.g., metoprolol), antiarrhythmics (e.g., propafenone, flecainide), warfarin (monitor INR), caffeine (reduced clearance), cyclosporine (monitor levels).

How to store Terfine 250

Store below 25°C in a dry place, protected from light and moisture. Keep out of reach of children.

Expert advice for Terfine 250

Terfine 250mg Tablet helps treat fungal infections of the skin and nails. Do not skip any doses and finish the full course of treatment even if you feel better. Treatment may be needed for 2 to 6 weeks for skin infections and 6 weeks to 6 months for nail infections. Your doctor may monitor your liver function regularly during treatment. Inform your doctor if you notice yellowing of eyes or skin, dark urine, or stomach pain. Inform your doctor if you are pregnant, planning to conceive or breastfeeding.

Manufacturer and class

Manufacturer:

BIOSWIZZ PHARMACEUTICALS LTD

Therapeutic class:

Antifungal

Drug class:

Allylamine antifungal (squalene epoxidase inhibitor)

Chemical class:

Naphthalene derivative