Tofabrint 11 mg Tablet

Composition of Tofabrint 11 mg Tablet

Tofabrint 11 mg Tablet contains Tofacitinib (11mg). It belongs to the Janus kinase (JAK) inhibitor class of medicines.

Uses of Tofabrint 11 mg Tablet

• Treatment of moderate to severe rheumatoid arthritis
• psoriatic arthritis
• and moderate to severe ulcerative colitis (as prescribed by a specialist)
• usually when there is inadequate response/intolerance to other DMARDs/biologics

Key benefits

• Reduces joint pain and swelling in rheumatoid/psoriatic arthritis
• Improves physical function and quality of life
• Helps control inflammation and slow disease progression
• Helps induce and maintain remission in ulcerative colitis

How Tofabrint 11 mg Tablet works

Tofacitinib is a Janus kinase (JAK) inhibitor that reduces signaling of multiple inflammatory cytokines. This lowers immune-mediated inflammation and helps relieve symptoms and prevent disease progression in autoimmune conditions.

How to take Tofabrint 11 mg Tablet

Tablet (extended-release): take exactly as prescribed, usually once daily. Swallow whole with water; do not crush, break or chew. Can be taken with or without food; take at the same time each day. Regular lab monitoring (CBC, LFTs, lipids) is typically required.

Take it exactly as your doctor prescribed. Do not change the dose or stop early on your own.

Missed dose and overdose

If you miss a dose

If you miss a dose of Tofabrint 11mg Tablet, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.

If you take too much

An overdose of this medicine can seriously suppress the bone marrow and damage the liver. Do not wait for symptoms to appear — go to the nearest emergency department and take the pack or strip with you.

Side effects of Tofabrint 11 mg Tablet

Most side effects of Tofabrint are mild and settle as the body adjusts. Reported side effects include:

• Upper respiratory tract infection
• headache
• nausea
• diarrhea
• abdominal pain
• increased cholesterol
• elevated liver enzymes
• herpes zoster (shingles)
• urinary tract infection

Stop the medicine and seek help immediately for a rash, swelling of the face or lips, wheezing or difficulty breathing. Tell your doctor about any side effect that persists or worries you.

Safety advice for Tofabrint 11 mg Tablet

Warnings and precautions

Prescription-only immunosuppressant. Increased risk of serious infections (TB, bacterial, fungal, viral) and reactivation (TB/hepatitis); screen for TB and hepatitis before therapy and monitor. Risk of malignancy (including lymphoma and skin cancer), major adverse cardiovascular events, blood clots (DVT/PE) and death—use with caution especially in older patients, smokers, and those with CV risk factors; seek urgent care for chest pain, breathlessness, leg swelling. Monitor CBC (risk of anemia/neutropenia/lymphopenia), liver function and lipids. Avoid live vaccines during treatment; complete immunizations before starting if possible. Use caution/adjustment in hepatic or renal impairment as advised by doctor.

Do not take Tofabrint if

Not for anyone with a known allergy to this medicine or to any ingredient in the pack. Not for people with an active serious infection, or with severe liver or bone-marrow disease. Several of these medicines must not be used in pregnancy.

Interactions with other medicines

Strong CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin) may increase levels; strong CYP3A4 inducers (e.g., rifampicin, carbamazepine, phenytoin, St John’s wort) may reduce effect; other immunosuppressants/biologics (e.g., azathioprine, cyclosporine, tacrolimus, TNF inhibitors) increase infection risk; live vaccines should be avoided

How to store Tofabrint 11 mg Tablet

Store below 25°C in a dry place, protected from light and moisture. Keep in original blister pack and out of reach of children.

Expert advice for Tofabrint 11 mg Tablet

Tofabrint 11mg Tablet is used alone or in combination with other medicines for the treatment of rheumatoid arthritis, that did not improve with other anti-rheumatic drugs. It may take take 3 to 6 months to feel the maximum effect of this medication. Keep taking it as prescribed. Your doctor may get regular blood tests done to monitor your liver function, kidney function, blood counts, or cholesterol levels. Tofabrint 11mg Tablet can make it a bit harder for people to fight off infections. Inform your doctor if you have symptoms of an infection such as fever, chills, cough, and muscle aches. Your doctor may get TB (tuberculosis) skin test and a chest X-ray before starting treatment with this medication. Inform your doctor if you are pregnant, planning to conceive, or breastfeeding.

Manufacturer and class

Manufacturer:

BRINTON PHARMACEUTICALS

Therapeutic class:

Immunosuppressant / Antirheumatic (DMARD)

Drug class:

Janus kinase (JAK) inhibitor

Chemical class:

N- acylpiperidines