
Abione Tab
Intas Pharmaceuticals Ltd - Tablet - 10 S
Prescription required
Sodium Valproate (499.50mg) + Valproic Acid (217.50mg)
Valprol CR 750 is used for treatment of Epilepsy.
Medically reviewed by Dr. Balaji Krishnan, MBBS · Updated September 2026
Valprol CR 750 contains Sodium Valproate (499.50mg) + Valproic Acid (217.50mg). It belongs to the Anticonvulsant class of medicines.
Treatment of Epilepsy
VALprol -CR 750 Tablet works by stabilizing electrical activity in the brain. They increase the levels of gamma-aminobutyric acid (GABA), a natural chemical that helps calm nerve activity, and reduce excessive firing of brain cells. This combined action helps prevent the abnormal electrical signals that lead to seizures and supports effective seizure control in epilepsy.
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. VALprol -CR 750 Tablet should be taken with or after food.
Take it exactly as your doctor prescribed. Do not change the dose or stop early on your own.
If you miss a dose of VALprol -CR 750 Tablet, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
An overdose of this medicine can cause deep unconsciousness, slowed breathing and dangerous heart rhythm disturbance. Do not wait for symptoms to appear — go to the nearest emergency department and take the pack or strip with you.
Most side effects of Valprol CR are mild and settle as the body adjusts. Reported side effects include:
Stop the medicine and seek help immediately for a rash, swelling of the face or lips, wheezing or difficulty breathing. Tell your doctor about any side effect that persists or worries you.
| Pregnancy | Pregnancy UNSAFE |
|---|---|
| Breastfeeding | Breast feeding SAFE IF PRESCRIBED |
| Alcohol | Alcohol UNSAFE |
| Driving | Driving UNSAFE |
| Kidney | Kidney CAUTION |
| Liver | Liver UNSAFE |
| Habit forming | No |
Never stop or change an anti-epileptic on your own. Stopping abruptly can cause prolonged, dangerous seizures. Sodium valproate and divalproex must not be used by anyone who is pregnant or could become pregnant unless a specialist has confirmed there is no alternative — they cause serious birth defects and developmental problems. Effective contraception is essential. Seek urgent care for any rash, especially in the first weeks — a rash with fever, blistering or peeling can be life-threatening. Report yellowing of the eyes or skin, persistent vomiting, unusual bruising or severe tiredness at once. Tell your doctor about any change in mood or any thoughts of harming yourself. Take the same brand each time unless your neurologist has agreed to a change; switching can alter seizure control.
Not for anyone with a known allergy to this medicine or to any ingredient in the pack. Valproate-containing medicines are contraindicated in pregnancy for epilepsy unless no alternative exists, and in all women of childbearing potential without a pregnancy prevention programme. Several are not suitable in significant liver disease.
This group interacts very widely, including with contraceptives, blood thinners and other anti-epileptics. Give your doctor a full list of what you take. Hormonal contraception may become unreliable — ask your doctor which method to use.
Store below 30°C in the original pack, away from direct sunlight and moisture. Keep out of the reach of children.
Take it at the same time every day to maintain consistent levels in your body. Do not drive or do anything that requires mental focus until you know how VALprol -CR 750 Tablet affects you. Avoid consuming alcohol when taking VALprol -CR 750 Tablet, as it may cause excessive sleepiness or drowsiness. Monitor your weight during the treatment as VALprol -CR 750 Tablet can cause weight gain. Your doctor may monitor the level of medicine in your body, your blood counts, and liver function regularly throughout your treatment. Inform your doctor if you develop fever, stomach pain, nausea, or yellowing of your eyes or skin. Do not take VALprol -CR 750 Tablet if you are pregnant or planning to conceive or breastfeeding. Do not stop taking the medication suddenly without talking to your doctor, as it may increase the seizure frequency.

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The information on Valprol CR 750 is compiled from the manufacturer's prescribing information and the sources below, and is reviewed by a registered medical practitioner. It does not replace advice from your own doctor.