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Torrent Pharmaceuticals Ltd - 100 G
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Risperidone (3mg) + Trihexyphenidyl (2mg)
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Same composition, in stock now. Check with your doctor or pharmacist before you switch.
Zisper Plus is used for treatment of Schizophrenia.
Medically reviewed by Dr. Balaji Krishnan, MBBS · Updated September 2026
Zisper Plus contains Risperidone (3mg) + Trihexyphenidyl (2mg). It belongs to the Antipsychotic and Anti-dementia / anti-parkinsonian agent class of medicines.
Treatment of Schizophrenia
Zisper Plus Tablet is a combination of two medicines: Risperidone and Trihexyphenidyl. Risperidone is an atypical antipsychotic that works by balancing the levels of chemical messengers (dopamine and serotonin) to improve mood, thoughts, and behavior. Trihexyphenidyl is an anticholinergic that works on the nervous system and corrects some of the chemical imbalances that cause Parkinson's disease and certain side effects occurring during antipsychotic treatment.
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Zisper Plus Tablet may be taken with or without food.
Take it exactly as your doctor prescribed. Do not change the dose or stop early on your own.
If you miss a dose of Zisper Plus Tablet, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
An overdose of this medicine can cause deep drowsiness, a severe fall in blood pressure, abnormal movements and heart rhythm disturbance. It can cause severe confusion, abnormal movements, a very slow pulse and collapse. Do not wait for symptoms to appear — go to the nearest emergency department and take the pack or strip with you.
Most side effects of Zisper Plus are mild and settle as the body adjusts. Reported side effects include:
Stop the medicine and seek help immediately for a rash, swelling of the face or lips, wheezing or difficulty breathing. Tell your doctor about any side effect that persists or worries you.
| Pregnancy | Pregnancy UNSAFE |
|---|---|
| Breastfeeding | Breast feeding CONSULT YOUR DOCTOR |
| Alcohol | Alcohol UNSAFE |
| Driving | Driving UNSAFE |
| Kidney | Kidney CAUTION |
| Liver | Liver CAUTION |
| Habit forming | No |
Report any tremor, stiffness, restlessness or uncontrollable movements of the face, tongue or limbs to your doctor promptly — these can become persistent if not addressed. Seek emergency care for high fever with severe muscle stiffness, confusion and sweating. This is rare but life-threatening. These medicines can raise blood sugar, cholesterol and weight. Your doctor will monitor them — keep those appointments. Never stop suddenly; your doctor will reduce the dose gradually. Take care in hot weather — this group affects how your body regulates temperature. Never stop a Parkinson's medicine suddenly — this can cause a severe and dangerous deterioration. Dose timing matters a great deal in Parkinson's disease. Take it at exactly the times prescribed. Report sudden daytime sleep attacks, hallucinations, or new gambling, spending or other impulsive behaviour — these are recognised effects and the dose may need review. Rise slowly from sitting or lying; a drop in blood pressure on standing is common.
Not for anyone with a known allergy to this medicine or to any ingredient in the pack. Your doctor will assess suitability if you have heart disease, Parkinson's disease or dementia. Your doctor will assess suitability if you have heart, eye or psychiatric conditions.
Alcohol and sedatives add to the drowsiness. Tell your doctor about any medicine that affects heart rhythm. Anti-emetics such as metoclopramide and some antipsychotics can worsen Parkinson's symptoms. High-protein meals can reduce the absorption of levodopa — ask your doctor about timing.
Store below 30°C in the original pack, away from direct sunlight and moisture. Keep out of the reach of children.
Use caution while driving or doing anything that requires concentration, as Zisper Plus Tablet can cause dizziness and sleepiness. Avoid consuming alcohol while taking this medication, as it may lower its efficacy. It can cause dry mouth. Maintain good oral hygiene, drink water, chew sugarless gum, or suck on hard candy for the dry mouth. It may cause an increase in weight, blood sugar, cholesterol, and triglycerides (fat). Eat healthy, exercise, and monitor your levels regularly. Inform your doctor if you have glaucoma or trouble passing urine. Do not stop taking Zisper Plus Tablet without talking to your doctor first, as it may cause a worsening of symptoms.
Medicines with the same active ingredient (Risperidone (3mg) + Trihexyphenidyl (2mg)). Ask your doctor or pharmacist before switching brands.
| Medicine | Pack | Price | vs Zisper Plus |
|---|---|---|---|
| Don Plus TabletCRESCENT FORUMULATIONS PVT LTD | tablet · 10`S | ₹78 | 27% more |
| Risdone PlusIntas Pharmaceuticals Ltd | 10`S | ₹92 | 49% more |

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The information on Zisper Plus is compiled from the manufacturer's prescribing information and the sources below, and is reviewed by a registered medical practitioner. It does not replace advice from your own doctor.