Drug | Tablet

Treatment of hypertension (high blood pressure), Blood pressure control in patients requiring combination therapy, Helps reduce risk of cardiovascular events such as stroke and heart attack associated with uncontrolled hypertension

Amlodipine is a calcium channel blocker that relaxes blood vessels by reducing calcium entry into vascular smooth muscle. Losartan is an angiotensin II receptor blocker (ARB) that blocks angiotensin II–mediated vasoconstriction and aldosterone effects. Together they lower blood pressure and improve blood flow.

Take as prescribed by the doctor, usually once daily at the same time each day. Can be taken with or without food; swallow tablet with water. Do not stop abruptly without medical advice; monitor blood pressure regularly.

Dizziness, headache, flushing, ankle/foot swelling (edema), fatigue, low blood pressure, palpitations, nausea, increased potassium (hyperkalemia)

May cause dizziness—avoid driving/operating machinery if affected. Monitor blood pressure, kidney function and serum potassium, especially in elderly, dehydrated patients or those with kidney disease. Use caution in heart failure, severe aortic stenosis, and liver impairment (amlodipine). ARBs like losartan should be avoided in pregnancy; stop immediately if pregnancy occurs. Seek medical help for facial/lip swelling or breathing difficulty (angioedema).

Potassium supplements/potassium-sparing diuretics (risk of hyperkalemia), NSAIDs (may reduce antihypertensive effect and worsen kidney function), lithium (increased lithium levels/toxicity), other antihypertensives/diuretics (additive BP lowering), ACE inhibitors or aliskiren (increased risk of renal impairment/hyperkalemia; avoid with aliskiren in diabetes), grapefruit juice (may increase amlodipine levels in some patients), strong CYP3A4 inhibitors/inducers (may alter amlodipine levels)

Store below 25°C in a cool, dry place away from moisture and direct light. Keep in original blister pack and out of reach of children.

Amlopres-L Tablet, Amlovas-L Tablet, Amlogard-L Tablet, Losar-A Tablet, Amlodac-L Tablet