Azmarda 100MG Tab

Tablet

Treatment of chronic heart failure with reduced ejection fraction (HFrEF) to reduce risk of cardiovascular death and hospitalization for heart failure.

Sacubitril inhibits neprilysin, increasing levels of natriuretic peptides to promote vasodilation and sodium excretion. Valsartan blocks angiotensin II (AT1) receptors, reducing vasoconstriction and aldosterone effects. Together they lower cardiac workload and improve heart failure outcomes.

Oral tablet. Take exactly as prescribed, usually twice daily, with or without food, at the same times each day. Do not take with an ACE inhibitor; allow a 36-hour washout when switching from an ACE inhibitor to sacubitril/valsartan. Dose may be started lower and titrated based on blood pressure, kidney function and potassium.

Low blood pressure (dizziness), increased potassium (hyperkalaemia), kidney function impairment, cough, nausea, diarrhoea, headache, fatigue, angioedema (rare but serious)

Contraindicated in pregnancy; stop immediately if pregnancy occurs. Do not use with ACE inhibitors (need 36-hour washout) or in patients with history of angioedema related to ACEI/ARB. Use caution in low blood pressure, dehydration, kidney disease, renal artery stenosis, hyperkalaemia, severe liver impairment; monitor blood pressure, serum creatinine and potassium. Avoid in diabetic patients taking aliskiren; caution with severe renal impairment. Seek urgent care for swelling of face/lips/tongue or breathing difficulty (angioedema).

ACE inhibitors (contraindicated), aliskiren (avoid esp. in diabetes), potassium supplements/salt substitutes and potassium-sparing diuretics (e.g., spironolactone, eplerenone, amiloride) may increase potassium, NSAIDs may worsen kidney function, lithium may increase lithium levels/toxicity, other antihypertensives/diuretics may increase hypotension risk.

Store below 30°C in original pack, protect from moisture and light. Keep out of reach of children.

Entresto 100 mg Tablet, Vymada 100 mg Tablet, Arnipin 100 mg Tablet, Sacubitril/Valsartan 100 mg Tablet (generic), Saci-V 100 mg Tablet