Gemerdapa 5/2/500 Tablet

Oral tablet; take exactly as prescribed by the doctor, usually once daily with food (preferably with the first main meal) to reduce stomach upset. Swallow whole with water; do not crush/chew. Monitor blood glucose regularly.

Metformin decreases hepatic glucose production and improves insulin sensitivity. Glimepiride (a sulfonylurea) increases insulin release from pancreatic beta cells. Dapagliflozin (an SGLT2 inhibitor) increases urinary glucose excretion by reducing glucose reabsorption in the kidneys.

Risk of hypoglycaemia (higher with missed meals, alcohol, heavy exercise or with other antidiabetics); metformin-associated lactic acidosis (seek urgent care for rapid breathing, severe weakness, abdominal pain); stop metformin temporarily before/after iodinated contrast procedures and during severe illness/dehydration; dapagliflozin may cause dehydration/low BP, ketoacidosis (can occur with normal sugars), serious genital infections; monitor renal function—use not recommended in severe kidney impairment; caution in elderly and those on diuretics; not for type 1 diabetes.

Insulin/other sulfonylureas (increased hypoglycaemia), diuretics (increased dehydration/hypotension), ACE inhibitors/ARBs (may enhance glucose lowering), corticosteroids and sympathomimetics (raise glucose), rifampicin (may reduce glimepiride effect), azole antifungals/clarithromycin (may increase glimepiride effect), alcohol (increases hypoglycaemia and lactic acidosis risk), iodinated contrast media (lactic acidosis risk with metformin), carbonic anhydrase inhibitors like topiramate (may increase acidosis risk)

Store below 25°C in a dry place, protected from light and moisture. Keep in original blister pack and out of reach of children.

Xigduo G 5/2/500 Tablet, DapaGlim M 5/2/500 Tablet, Daparyl M 5/2/500 Tablet, Forxiga GM 5/2/500 Tablet, Dapaglif M 5/2/500 Tablet