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Plasma volume expansion in hypovolaemia/shock due to blood or plasma loss (e.g., trauma, surgery, burns), peri-operative volume replacement when crystalloids are inadequate

Polygeline is a colloid plasma expander that increases intravascular oncotic pressure and expands circulating plasma volume. This improves venous return and blood pressure, helping restore perfusion during acute volume depletion.

For intravenous infusion only; administer under medical supervision with dose and rate based on clinical status (blood loss, haemodynamics, urine output). Can be given through standard IV set; monitor vitals and signs of fluid overload; not a substitute for blood when oxygen-carrying capacity is required.

Allergic/anaphylactoid reactions (rash, urticaria, bronchospasm), fever/chills, nausea, vomiting, flushing, hypotension, tachycardia, headache, injection site reactions, fluid overload/pulmonary oedema

Use with caution in cardiac failure, hypertension, renal impairment, severe anaemia, and patients at risk of fluid overload; monitor electrolytes and haemodynamics. Risk of hypersensitivity reactions—stop infusion immediately if reaction occurs and treat appropriately. Large volumes may cause haemodilution and can affect coagulation; use cautiously in bleeding disorders and monitor coagulation if high volumes are used. Not for intramuscular or oral use.

Additive risk of fluid overload with other IV fluids/blood products; concomitant diuretics/antihypertensives may influence blood pressure response. Do not mix with other medicines in the same IV line unless compatibility is known.

Store at room temperature (typically below 25°C), protect from excessive heat and freezing; keep in original container; use only if solution is clear and container intact.

Gelofusine 500 ml infusion, Gelaspan 500 ml infusion, Haemaccel infusion (other marketers), Polygeline 3.5% IV infusion 500 ml (generic)