Isotroin 10 Caps

Capsule

Treatment of severe nodular/cystic acne (acne vulgaris) not responding to adequate courses of standard therapy including systemic antibiotics and topical treatments

Isotretinoin is an oral retinoid that reduces sebaceous gland size and sebum production. It also normalizes follicular keratinization and has anti-inflammatory effects, thereby reducing acne lesions.

Oral capsule; take exactly as prescribed by a dermatologist. Usually taken once or twice daily with food (preferably with a fatty meal) to improve absorption; swallow whole with water, do not crush/chew. Follow the full course and regular follow-ups/lab tests.

Dry lips, dry skin, dry eyes, nosebleeds, skin peeling, photosensitivity, headache, muscle/joint pain, increased liver enzymes, increased triglycerides, mood changes

Highly teratogenic: contraindicated in pregnancy and during breastfeeding; strict pregnancy prevention program required (effective contraception, pregnancy tests before/during/after therapy). Do not donate blood during treatment and for at least 1 month after stopping. Monitor liver function and lipids; use caution in history of depression, diabetes, hyperlipidaemia, liver disease. Avoid excessive sun/UV exposure; use sunscreen. Avoid vitamin A supplements and tetracycline antibiotics (risk of raised intracranial pressure). May reduce night vision; caution while driving at night. Do not use for mild/moderate acne unless advised.

Tetracyclines (e.g., doxycycline/minocycline), vitamin A/retinoid supplements, alcohol (worsens hypertriglyceridaemia/hepatotoxicity risk), hepatotoxic medicines, corticosteroids (bone effects), phenytoin (bone effects), St John’s wort (may reduce contraceptive efficacy)

Store below 25°C in a cool, dry place, protected from light and moisture. Keep in original blister pack; keep out of reach of children.

Tretiva 10 Capsule, Sotret 10 Capsule, Isoft 10 Capsule, Accutane 10 mg Capsule, Isotroin 20 Capsule (dose alternative)